جستجوی مقالات مرتبط با کلیدواژه « گیاهان شفابخش » در نشریات گروه « پزشکی »

Nowadays, considering the increase in the consumption of medicinal plants, there is the possibility of poisoning with some poisonous plants due to the lack of sufficient information of non-specialists regarding their toxicity. Also, not enough data exists about their antidotes, so it seems important to introduce poisonous plants and their antidotes. This library research was conducted using a descriptive and comparative method from Avicenna's book, Canon of Medicine. Moreover, phytopharmacological findings on the mechanisms of the antidote effect of plants were discussed in a comparative manner using reliable scientific internet databases such as Science Direct, PubMed, Scopus, Springer, and SID. Avicenna has provided instructions for the treatment of plant poisonings, such as cleansing the digestive system from toxins via inducing vomiting, and using laxatives and enemas. To cleanse the the blood and lymph, he recommends diuretics, diaphoretics, and antidotes to neutralize the toxins. In this study, 38 poisonous plants and their antidotes were discussed. According to the findings of this research, there exist natural antidotes with minimal side effects. These antidotes have been validated for their efficacy through contemporary scientific research. Through the implementation of laboratory and clinical studies, these natural antidotes can potentially serve as primary antidotes for certain poisonous plants.

Convulsive disorders are among chronic diseases, which usually need a long-term drug therapy. Unfortunately, most of the drugs used clinically to treat these disorders exert many side effects. Therefore, search for finding new drugs is being carried out in many laboratories.

The object of this research was to compare the anticonvulsive effect of the aqueous extract of the plant Melissa officinalis with Phenobarbital in Pentylenetetrazol (P)-induced seizures on mice.

After acclimatization, animals were randomly divided in different groups. Control group received normal saline (6ml/kg), standard groups received (10, 20, 30 and 40 mg/kg) Phenobarbital and the test groups received aqueous plant extract (3, 6, 9 and 12 ml/kg). All injections were carried out as i.p. All animals were firstly exposed to P (80mg/kg, i.p). The onset of seizures, behavioral changes, duration of the seizures and number of deaths were recorded in all groups during the first 24 hours.

All doses of the plant extracts delay the onset of seizures but the most effective dose was 12ml/kg, which was comparable to phenobarbital (30mg/kg). All amounts of the extract, except 3ml/kg, significantly reduced the duration of seizures compared to the control group. Number of deaths was 45 and 10 percent in control, standard and test groups, respectively.

Findings showed that 12ml/kg of the aqueous plant extract is able to reduce the onset of seizures, duration of seizures and number of deaths after 24 hours in Pentylenetetrazol-induced seizures.

Considering the high prevalence of Tricomonas vaginalis (TV) in women and the known side effects of Metronidazol, the focus has been concentrated on herbal therapy in order to reduce drug side- effects in the recent decades.

To determine of M.communis effect on Trichmonas Vaginalis infection.

This study has been carried out as double blind in test and control groups. Methanolic extraction was performed by percolation and essential oil prepared by hydrodistillation. The parasite was isolated from vagina and determined directly. Samples were collected from vaginal discharges. Identification were done through direct smear preparation. Parasite was added to the 5 test tubes containing Drosse medium, metronidazole, Dimethyl sulfoxaide (DMSO) myrtus extraction with concentration of (0.1, 0.01 ml and essential oil with concentrations of (0.1, 0.01, 0.001, 0.004, 0.0002 and 0.0001) in order to determine the effect of these concentrations within 72 hours.

Findings suggested that Trichomonas could be alive in Drosse medium for 72 hours, in presence of Metronidazole for one hour and in Drosse medium for 6 hours. Also, the results revealed that methanolic extract at concentrations of 0.1 and 0,01 and essential oil at concentrations of 0.1, 0.01, 0.001 and 0.0004 were effective at the beginning of the inoculation and at concentrations of 0.0002 and 0.0001 after 2 and 9 hours respectively.

Considering the significant effect of essential oil and methanolic extract of M.communis on Trichomonas in-vitro condition, it is recommended that the therapeutic effects of the substance from this plant be studied in- vitro condition and if having positive effect, to be used as a drug.

Peroxides is a glycoprotein that contains hem group and variable cationic and anionic is enzymes. This enzyme is used in laboratory diagnosis for determination of hormones and bacterial toxins with ELISA method , detection of tissue antigens and macrophage activation against tumoral cells. In addition , this enzyme is used for measurement of glucose, urea, uric acid and cholesterol. Although peroxides is widely seen in available sources of plants, this enzyme for meeting the consuming needs of our country is imported from abroad with high foreign currency costs.

This experimental study was conducted for separation and purification of peroxides is enzymes from cultivated radish which is cheap and abundant in all seasons in Iran.

Extraction was carried out by homogenization of plant roots and concentration of Ammonium sulfate. Then, purification method was followed by gel filtration, cationic exchange chromatography. Finally, separation of basic and acidic is enzymes was conducted by different and repeated column chromatography and SDS-PAGE.

As a result of these procedures, Purification degree obtained was 168.5 folds more than the raw extract and specific activity was comparable with commercial peroxides .

As this enzyme is stable at wide range of PH and temperature, we can economize its purification methods to a great extent and achieve the maximum required foreign currency savings. It is hoped that with the use of wide and cheap sources , we can take an effective step toward large scale production of the enzyme in our country and avoid spending our financial resources in purchasing peroxides from foreign countries.