جستجوی مقالات مرتبط با کلیدواژه « 1β » در نشریات گروه « پزشکی »

Periodontal diseases are multifactorial conditions that are induced in the presence of bacteria and under the influence of environmental and genetic factors. Management of environmental factors might help prevent such diseases. The aim of this study was to investigate the relationship between interleukin-1α، β gene polymorphism and chronic periodontitis (CP). This case-control study included 36 subjects with chronic periodontitis referred to Periodontology Department of Khorasgan Dental School and 36 periodontally healthy controls، with an ethnic origin of Isfahani Iranian race. Extracted DNA from peripheral blood was used to evaluate interleukin-1α، β gene polymorphism. Data were analyzed using chi-squared and Fisher’s exact tests (α=0. 05). There was a significant association between IL-1α -889، 2/2 genotype and CP and between IL-1α -889 allele and periodontal health (p value = 0. 03). There was no significant association between IL-1β +3954 genotype and CP (p value = 0. 14). There was no significant association between IL-1β +3954 alleles and CP (p value = 0. 06). Based on the results of the present study، association between IL-1α -889 polymorphism in the population presented here confirms this gene as a risk factor for CP. However، the lack of any association between IL-1β +3954 polymorphism and CP makes it dubious to use this gene as a marker of susceptibility to CP.

Statement of Problem: Periodontitis is a chronic multi-factorial infectious disease,characterized by irreversible destruction of collagen fibers and other matrix constituents of the gingival tissues, periodontal ligament and resorption of the alveolar bone around the teeth with formation of periodontal pocket. Cytokines such as IL-1β are one of the components of host’s immune system and seem to play an important role in periodontitis The aim of this study was to determine the concentration of IL-1β as a per-inflammatory cytokine in the saliva of periodontally involved patients (generalized aggressive periodontitis and mild to moderate periodontitis) and subjects with normal periodontium. In this experimental study, unstimulated saliva of 24 patients with mild to moderate chronic periodontitis, 15 patients with aggressive periodontitis, and 23 subjects with healthy periodontium was collected. The concentration of IL-1β was measured in the saliva samples by ELISA. Mann-Whitney test was used for analysis of data. The results of this study showed that there was a significant difference between mean level of IL-1ß in generalized aggressive periodontitis vs. control groups and chronic mild to moderate periodontitis vs. control groups (p <0.05). The findings of the present study showed that the mean concentration of IL-1ß in the saliva of periodontally involved patients was greater than that of healthy subjects and this cytokine can be agood marker for determining the status of periodontal tissues.