جستجوی مقالات مرتبط با کلیدواژه "ami" در نشریات گروه "پزشکی"

Blood urea nitrogen (BUN) and serum creatinine (Cr) levels are the risk factors associated with prognosis in patients with the acute coronary syndrome. This study aimed to investigate whether BUN and Cr have a predictive value in patients diagnosed with acute myocardial infarction (AMI) and their mortality. This descriptive-analytical study was performed retrospectively by referring to the archives of Shahid Sadoughi Hospital in Yazd, Iran. The participants were 131 patients with acute myocardial infarction whose files were accessible from 2014 until 2018. Parameters such as age, sex, type of stroke, Cr and BUN levels at the time of admission, and outcome were examined. A questionnaire was used to collect data. Data analysis was performed using SPSS software version 21, and graphs were drawn with Sigma Plot software version 12.5. Data analysis showed no significant difference between Cr and BUN levels between men and women (P = 0˃05). The levels of both of these factors elevated with age in the patients (BUN: P ≤ 0.01), (Cr: P ≤ 0.05). In addition, both Cr (P ≤ 0.05) and BUN (P ≤ 0.001) had higher levels in the deceased patients than in the discharged ones.  The results revealed that in addition to elevated Cr and BUN, which are indicators of renal function, age is a significant risk factor in predicting mortality in AMI patients.

Selenium (Se) is part of the enzyme glutathione peroxidase (GSH – Px) that plays an important role in the antioxidant defense of the body. Evidence has demonstrated that populations with low intake of selenium in the diet have a 2-3 fold risk of ischemic heart disease. Positive statistically significant correlations have been found between trace element concentrations (Cu, Zn, Se) of heart tissue with physiological parameters (CO: cardiac output, EF: ejection fraction) of the heart. Increased plasma concentration of TNF-α has been found in patients with coronary artery disease. Stressed myocardium activates pro-inflammatory cytokines, such as TNF-α, which produce abnormalities in myocyte contractile function. This study was done to determine the circulating levels of Cu, Zn, Se, IL- 6, TNF - α, and erythrocyte GSH - PX activity in two groups of patients with chronic coronary artery disease (CCAD), acute myocardial infarction (AMI) and normal individuals (IHD-free).
Patients were divided into two groups: 25 with chronic CAD (CCAD) and 25 with acute myocardial infarction (AMI). The control group was 50 normal individuals that did not have any symptoms for IHD, and was gender and age-matched with the patients. Blood samples were collected during the first hours after the onset of chest pain in the acute MI group. Serum levels of Se, Cu, and Zn were determined by atomic absorption spectrometry, TNF-α and IL-6 were measured with ELISA and erythrocyte GSH-PX activity with Paglia and Valentine methods.
In both groups of patients, there was a significant reduction of Se in the serum (82.36±11.31 micg/l in CCAD, 74.08±11.31 in AMI vs. 105±32.52 in control group, P-value=0.03). No Trace Element Levels in Acute and Chronic CAD M. Hassanzadeh MD, et al statistically significant difference was found in Zn and Cu serum levels (0.98±0.22 and 112±18 in CCAD and 0.98±0.4 and 115±20 in AMI vs. 0.96±0.24 and 114±17 in control group). TNF-α titers showed a significant difference in AMI patients compared to CCAD and control groups
(mean TNF-α level 37.44 pg/ml in CCAD, 914.32 pg/ml in AMI and 4.80 pg/ml in control group, P value 0.01). Serum levels of IL-6 in the two groups of CCAD and AMI patients were 3.28±15.55 and 472±207.88 pg/ml, respectively, compared to 1.28 pg/ml in the control group, P= 0.001 ).
These findings confirm the previous studies and demonstrate that patients suffering from AMI exhibit a lower plasma concentration of selenium and TNF-α and IL - 6 significantly increase during the first hours of AMI. Selenium concentration of whole blood was lower in the two patient groups (CCAD, AMI) compared to the control group. GSH - PX activity has a strong inverse association with CAD .