جستجوی مقالات مرتبط با کلیدواژه "coagulation disorders" در نشریات گروه "پزشکی"

Coagulation disorders involve a wide range of medical issues resulting from a deficiency or absence of certain coagulation factors in plasma. While existing therapies exist, herbal medicine presents an alternative and effective approach for treating bleeding disorders. Terminalia chebula Retz has been reported for its efficacy in ethnobotanical practices for bleeding stopping.

  The in vivo effectiveness of T. chebula Retz as an herbal medicine was examined using mice.

Thirty-two mice were randomly divided into three treatment groups (n = 8) receiving different doses (2000, 1000, and 500 mg/kg/day), along with a negative control group. Blood samples were collected from the tail and heart on the 16th and 18th day of treatment, respectively, to determine coagulation parameters, including bleeding time (BT), clotting time (CT), prothrombin time (PT), activated partial thromboplastin time (aPTT), and platelet count (PLT).

The results demonstrated the effectiveness of T. chebula hydroalcoholic extract in promoting primary and secondary homeostasis. There was a significant decrease in bleeding time (70 %) and a substantial increase in platelet count (80 %). Moreover, the extract led to a notable reduction in clotting time (80 %) indicating its impact on primary homeostasis through platelet aggregation. Additionally, T. chebula extract shortened the coagulation time in both PT (70 %) and aPTT (20 %) tests, reflecting its influence on the extrinsic and intrinsic pathways of secondary hemostatic parameters, respectively.

In conclusion, the optimal concentration (500 mg/kg/day) of hydroalcoholic extract of T. chebula appears to be effective in promoting blood coagulation through primary and secondary homeostasis.

Orthotopic liver transplant (LT) is often associated with massive blood loss and significant transfusion requirements. Recent recommendations for resuscitation strategy in bleeding patients include transfusion of balanced blood products, fresh frozen plasma (FFP), platelets, red blood cells (PRBC), and restricted use of crystalloids.

To evaluate whether the intraoperative transfusion ratio of fresh frozen plasma to packed red blood cells units (FFP: PRBC ≤1:1 versus >1:1) plays a positive role in reducing PRBC transfusion in LT.

This is a retrospective study of 84 liver transplant recipients who received at least one PRBC unit during the surgery. The patients were grouped: into those who received intraoperative FFP: PRBC ratio ≤ 1:1 (low) versus the ratio > 1:1 (high). Selected perioperative variables were compared between the two groups. The variables included; baseline characteristics of the patients, intraoperative transfused PRBC and blood products, postoperative mean hemoglobin, platelets, international normalized ratio, postoperative transfused PRBC and blood component, early postoperative complications as re-operation due to bleeding, portal vein thrombosis, and duration of stay in the intensive care unit.

There was a significant difference between the two groups in preoperative BMI (P = 0.04) and hemoglobin (P = 0.005), and the two variables were higher in the high-ratio group. Patients in the ≤1: 1 group versus >1:1 had lower intraoperative requirements for PRBC (P<0.001). Importantly, the postoperative mean PRBC transfused units in the high ratio group were 1.76 times that of the low ratio group (incidence rate ratio [IRR], 1.76; 95% CI, 1.07 –2.90).

In patients undergoing LT, intraoperative plasma transfusion with a PRBC ratio of ≤1:1 was associated with a reduced need for PRBC transfusion.

Evidence suggests that COVID-19 patients are subject to significant risks of thromboembolic complications.

We aimed to evaluate coagulation disorders in COVID-19 patients and determine their relationship with the disease outcome.

This cross-sectional study was conducted on 106 COVID-19 patients hospitalized in Imam Khomeini Hospital, Ardabil, Iran. After the preliminary completion of the information forms, 3 cc of intravenous blood sample was taken from each patient to test for INR, PT, CBC, and D-dimer. Then, the patients were monitored, and clinical data were statistically analyzed using SPSS software, version 24.

Of 106 COVID-19 patients, 69 were discharged from the hospital, while 37 cases died. The mean age of the patients was 58.99 ± 15.94 years, and 56.6% were males. Significant differences were found between the surviving and deceased patients in D-dimer, LDH, PT, and INR levels (P < 0.05). Based on logistic regression analysis, only D-dimer was a significant predictor of mortality such that each unit increase in the D-dimer level increased the mortality risk by 0.99%.

D-dimer has a higher sensitivity than other coagulation markers in terms of intensity. As bleeding is not as common as thrombotic events, anticoagulant therapy is recommended.

Postpartum pyrexia results from various causes with bacterial infection heading the list. However, there are many other possible causes such as bleeding. Congenital deficiency of the coagulation factors causes inherited coagulopathies most of which are rare. Following delivery, the reduction in coagulation factors puts these mothers at greater risk ýof postpartum excessive bleeding.
We aimed to assess ýpostpartum pyrexia in bleeding disorder mothers.ý
This ýstudy was conducted on 98 bleeding disorder patients and 199 controls. Using a standardized questionnaire, the data were collected by consulting a specialist. The subject`s medical records during pregnancy and labor were also reviewed. Postpartum fever ýwas defined as temperature >ý 38°C ýin the first 10 days after delivery ýýýexcluding the first day.ý The data were analyzed using Chi-square statistical analysis and P Postpartum pyrexia was detected in 11.2% of the patients compared to 4% of the controls. The statistical analysis revealed a significantly higher incidence of postpartum fever among the coagulation disorder patients (P = 0.019). Considering the infection, our data showed that in the patient group, fever was mostly due to (unknown) reasons other than infection.
Our results revealed that besides hemorrhagic complications in inherited bleeding disorders, postpartum fever could also be a sign of threat. Early identification and diagnosis of these threats greatly improve the childbirth outcomes in high-risk mothers.

Factor XIII deficiency is a relatively rare hereditary bleeding disorder, which is usually found during infancy or early childhood. This condition may involve both genders within different races in an equal manner. Its incidence is estimated at approximately 1 in 106 live births. Patients with factor XIII deficiency are presented with a pattern of neonatal hemorrhage and lifelong bleeding diathesis..
A five-year-old female is presented here, who was diagnosed as a definite case of factor XIII deficiency, based on the clinical and laboratory findings at a medical specialist clinic. Typical clinical features of the disorder were the chief complaint of the patient, which was severe bleeding when she was brought into a specialized dental office following an earlier dental procedure..
The case was fully investigated and diagnosed as a case with factor XIII deficiency causing such uncontrolled bleeding after extraction of a tooth..