جستجوی مقالات مرتبط با کلیدواژه "coconut oil" در نشریات گروه "پزشکی"

Burns is one of the most severe forms of trauma that cause damage to the skin and subcutaneous tissues in different ways with different severity and extent. Effective reduction of itching symptoms after burns is a major problem in rehabilitating all burn patients. However, although there are many potential treatments for pruritus, there is still no consensus on the best treatment. This study was conducted to investigate and compare the effects of cetirizine, gabapentin, and coconut oil in reducing skin itching after burn wound healing.

The present research population was selected from among the patients of Amir-Al-Momenin burn hospital affiliated with Shiraz University of Medical Sciences who suffered from mild to severe burns that are resistant to treatment and sometimes have bleeding. In this study, after the approval of the ethical committee of the University Research Council and the consent of the patients, 150 people were selected by random sampling. To collect data from the studied sample, the questionnaire of Khars Yusipovich et al. (2001) was used. The obtained data were statistically analyzed using t-correlated and covariance analysis and with the help of SPSS.

The average and standard deviation of the itchiness of the burn site before the cetirizine drug is 4.32 and 0.74. Also, the average and standard deviation of the itchiness of the burn site after the cetirizine drug is equal to 3.04 and 1.57. The mean and standard deviation of the itchiness of the burn site before the gabapentin drug are equal to 4.98 and 0.82. Also, the average and standard deviation of the itchiness of the burn site after the gabapentin drug is equal to 1.66 and 0.47. The average and standard deviation of the itchiness of the burn site before coconut oil is equal to 4.40 and 1.76. Also, the mean and standard deviation of the itchiness of the burn site after coconut oil is equal to 1.60 and 0.49. The intensity of itching was measured before and after the administration of cetirizine, gabapentin, and coconut oil, and there was a significant difference between all three groups.

This study showed that all three drugs, cetirizine, gabapentin, and coconut oil, reduce itching after burns and coconut oil showed the greatest effect, followed by gabapentin and finally cetirizine. The long-term follow-up of patients after discharge from the hospital showed that after transplant surgery, itching was less and that patients who lived in cold areas experienced less itching after burns.

Constipation is one of the most common digestive problems in pregnant women which is commonly associated with hemorrhoids. Patients' non-compliance with lifestyle modification recommendations leads to failure of treatment with this method. Although therapeutic properties of coconut oil on constipation are discussed, but its scientific documentation has not been reported; therefore, this study was performed with aim to determine the effect of coconut oil ointment on the symptoms of constipation in pregnant women with hemorrhoids.

This randomized clinical trial study was performed on 60 pregnant women who referred to Mashhad Comprehensive Health Service Centers in 2018-2019. Eligible individuals were divided into two groups. The control group received only lifestyle modification recommendations, while the intervention group in addition to these recommendations used an applicator of coconut oil ointment twice a day for two weeks. The improvement of constipation symptoms including need for straining during defecation, hard stools and defecation less than 2 to 3 times a week was assessed using the Constipation Questionnaire in Pregnancy. Data were analyzed using SPSS software (version 16) and Chi-square, Fisher exact and Cochran tests. P< 0.05 was considered statistically significant.

The frequency of need for straining during defecation on the fourteenth day after the intervention in pregnant women in the coconut oil ointment group was significantly lower than the control group (p <0.05). In the intragroup comparison, it was found that in the group of coconut oil ointment, the difference in the need for straining during defecation and hard stools according to the day of measurement was significantly different (P <0.001), while in the control group, the difference in the need for straining during defecation and hard stools according to the day of measurement was not significant (p <0.05). In the intragroup comparison, defecation less than 2 to 3 times a week, although clinically was associated with a decrease in the coconut oil ointment group, but this decrease was not statistically significant (p=0.050).

Coconut oil ointment is effective in improving the symptoms of constipation in pregnant women with hemorrhoids, so its use is recommended in these people.

A high-fat diet can disrupt the antioxidant system and damage the liver. One of the most important ways to control non-alcoholic fatty liver is to use natural compounds with antioxidant properties. Therefore, this study was performed to evaluate the effect of coconut oil on cholesterol, triglyceride and antioxidant status in high-fat diet- induced rat liver.

In this experimental study, 30 male rats were randomly divided into 6 groups of 5 including: 1) control group, 2 and 3) control+10% and 8% virgin coconut oil, 4) only receiving high fat diet, and 5 and 6) receiving high fat diet+10% and 8% virgin coconut oil. Coconut oil was prepared daily and mixed with animal food. At the end of the study, the rats were anesthetized and liver tissue was isolated and used for antioxidant tests.

In this study, the levels of triglyceride (159±11.5) in the high-fat diet group increased significantly compared to the control (64±4.2) (p<0.001). Treatment of high-fat diet group with coconut oil at doses of 8% (104.5±9.1) and 10% (97.5±8.2) was able to reduce triglyceride levels (p<0.05) significantly. Cholesterol (118±6.7) in the high-fat diet group increased significantly compared to the control (60±6.6) (p<0.001). Treatment of high-fat diet group with coconut oil at a dose of 10% (94±5.3) was able to reduce cholesterol (p<0.01) significantly.

According to the results of this study, virgin coconut oil can be useful in the treatment of fatty liver by reducing lipids and increasing antioxidants.

Prematurity and low birth weight are one of the major health problems and the most common causes of infant mortality. Infant massage is potentially beneficial for physiological and psychological health. The present study was conducted to compare the effect of massage with coconut oil and sunflower oil on the growth of premature infants.

This clinical trial was performed on 100 premature infants admitted to the neonatal intensive care unit of Amirkola Childrenchr('39')s Hospital in 2018 in four groups of 25 infants. Infants of the intervention groups with one cc of sunflower oil and coconut oil and the oil-free massage group were massaged for 15 minutes three times a day for seven days with the help of a research assistant, and the control group received only routine care. The weight, height, and head circumference of infants were collected using a personal profile questionnaire and compared in four groups at the beginning and end of the intervention.

Comparison of mean weight and head circumference changes at the end of the first week between coconut oil massage group (0.134±0.334 cm, 6.81±3.04 g), sunflower oil massage group (0.239±1.172 cm, 6.35±2.69 g), oil-free massage group (1.061±1.534 cm, 2.95±2.65), and control group (0.663±1.174 cm, 3.52±4.38 g) showed significant difference (p<0.05). Comparison of mean height changes in different groups (0.413±0.739, 0.448±0.747, 0.458±0.693, 0.429±0.611 cm, respectively) did not show any significant difference.

The results of the study showed that oil massage is recommended as it increases the rate of changes in weight gain and head circumference in premature infants.

Hemorrhoids is one of the most common problems during pregnancy. Lifestyle modification recommendations are associated with patients' noncompliance. The potential therapeutic properties of coconut oil on hemorrhoids have been suggested, but its scientific evidence has not been reported, therefore this study was performed with aim to determine the effect of coconut oil ointment on hemorrhoids symptoms in pregnant women.

This randomized clinical trial was performed on 60 pregnant women referred to comprehensive health services centers in Mashhad in 2018-2019. The subjects were randomly divided into intervention and control groups. In the intervention group, one applicator of coconut oil ointment was applied twice a day for two weeks; they also received lifestyle modification recommendations. The control group only received lifestyle modification recommendations based on national guidelines. The improvement of hemorrhoids symptoms was measured on the first, seventh and fourteenth days using Visual Analog Scale (pain, prolapse, itching and overall score of hemorrhoid symptom). Data were analyzed using SPSS software (version 16) and Mann-Whitney, Independent T and Friedman tests. P<0.05 was considered statistically significant.

The mean score of pain, prolapse, itching and overall score of hemorrhoid symptoms in coconut oil ointment group significantly decreased compared to the control group (p<0.05). In the intra-group evaluation, in the coconut oil ointment group, the pain score measured by day was significantly different (p<0.001) but in control group this difference was not significant (p=0.050).

Coconut oil ointment is effective in improving the hemorrhoids symptoms, therefore it is recommended for pregnant women with hemorrhoids grade 1 and 2.

Candidiasis is the second common vaginal infection, and commonly used drugs are azoles. Over-consumption of Azol is associated with resistance to drug and treatment failure. Studies conducted in vitro confirm the antifungal effects of coconut oil. The aim of this study was to compare the effect of vaginal cream of coconut oil and clotrimazole on vaginal candidiasis infection. This clinical trial study was performed on 71 women with Candida infection in two groups receiving vaginal cream of coconut oil: 35(78%) and clotrimazole (36%) (1%) who were treated for 7 nights (one applicator per night). One week after the completion of the treatment, patients were re-examined. Itching, burning, pain and secretion were compared in two groups. After the mean intervention (itching in the coconut group was 0±0 and in the clotrimazole group was 19±0.46 (p=0.017), (burning in the coconut group was 0.08±0.20 and in the clotrimazole group was 57% (p=0.046), (secretion in the coconut group was 0.05±0.23 and in the clotrimazole group was 66.6 ± 0.98 (p=0.001) (pain during sex in the coconut group 23 0.05 and 0.30±0.62 in the clotrimazole group (p=0.031). However, the success of the treatment (negative culture) was not significant between the two groups (p<0.05). The present study showed that vaginal cream of coconut oil and clotriamzole both improve vaginal candidiasis infection. Therefore, vaginal cream of coconut oil can be used as an alternative treatment for vaginal candidiasis

The incidence of vaginal candidiasis and the number of treatment resistant cases are high; moreover, chemical medications are associated with serious adverse effects. Therefore, the use of herbal medicines is taken into consideration because they do not affect the normal vaginal flora and have low side effects. In vitro studies confirmed the favorable antifungal effects of coconut oil on various species of Candida, especially on the resistant species such as Candida glabrata and Candida tropicalis. This study was conducted to compare the effect of vaginally administered coconut oil and clotrimazole on Candida species.
This triple-blind clinical trial was conducted on 71 patients, who were assigned into two groups of coconut oil (35 individuals) and clotrimazole (36 individuals) in Mashhad, Iran, 2017. Data were collected using demographic data form and observation record sheets. The patients received the medicines by applicator for a week. Thereafter, physical examination and re-cultivation were carried out; and the success in the treatment included a negative culture and symptom relief. Data analysis was performed using independent samples t-test, Fisher’s exact and Chi-squared tests with the help of SPSS software, version 19. P-value less than 0.05 was considered statistically significant.
In this study, there was no significant difference between the groups in terms of the frequency of Candida albicans, glabrata, and tropicalis at the pre- and post-intervention phases (P=0.98, P=0.34, P=0.73, respectively). Regarding the success in the treatment, no significant difference was observed between the effects of vaginally administered coconut oil and clotrimazole on various species of Candida (P>0.05).
Considering the beneficial effects of vaginally administered coconut oil on candidiasis, it is recommended to use it to treat this disorder.