جستجوی مقالات مرتبط با کلیدواژه « dental follicle » در نشریات گروه « پزشکی »

Background and Keratocystic odontogenic tumor tends to recur and behave more aggressively than follicular cysts and dental follicles. Eosinophils are multifunctional leukocytes, but their role in oral lesions is controversial. Current study aimed at assessing the density of eosinophils in aggressive odontogenic lesions.
In this descriptive-analytical cross-sectional study, paraffin blocks were obtained from Babol Dental School archives including 16 cases of keratocyst,19 follicular cyst, and 12 dental follicle and their demographic characteristics were extracted. The overall density of eosinophils and density of eosinophils in adjacent areas and away from odontogenic epithelium were examined in slides stained with Congo red in 10 microscopic fields (40x).
Eosinophil density was 0.08±0.3 in dental follicles, 1.7±2.1 in follicular cysts, and 6.14±5.6 in keratocystic odontogenic tumors. The eosinophil density in areas adjacent to odontogenic epithelium in keratocyst and follicular cysts was greater than that in areas away from odontogenic epithelium (P>0.001).
Based on current study, eosinophils appear to influence the pathogenesis of follicular cysts and keratocystic odontogenic tumors. Their increased density in keratocysts, especially in the vicinity of odontogenic epithelium, is effective in its aggressive behavior.

The follicular tissue around impacted third molar has a potential to develop to different lesions. However, it is generally accepted that the absence of abnormal radiolucency indicates the presence of a normal follicle. The aim of this study was to histopathologically evaluate the normal pericoronal radiolucencies associated with impacted third molars. The follicular space of 104 third molars with normal follicular space (<2.5mm) in panoramic radiographs was measured. Under local anesthesia, tooth and its follicle were taken out by surgical procedure and after necessary steps, were histopathologically evaluated. Data were analyzed by fisher's exact test, chi-square and logestic regression (=0.05). Thirty eight cases (36.5%) of all follicles had been collected from male, and 63.5% (66 cases) from female patients. 92 follicles (88.5%) had been taken out of mandible and 12 follicles (11.5%) from maxilla. Of the specimens submitted, 41.3% (43 cases) showed cystic changes equivalent to that in dentigerous cysts. Cystic changes in dental follicles were significantly higher in patients over 20 years of age (P<0.0001). No significant difference was detected between sex of patients and cystic changes in follicles (P>0.05). Impacted third molars with normal pericoronal radiolucency more than 1.5 mm showed cystic changes in 63.3% of the cases. This study confirms the idea that the risk of cystic changes increases with age. Considering the high incidence of cystic changes in pericoronal radiolucencies associated with impacted third molars, this study suggests prophylactic removal of impacted third molar.

The aim of this survey was immunohistochemical evaluation of MIB-1 expression in dental follicle and dentigerous cyst regarding to the capability of neoplastic changes and ability for more proliferation and more recurrence after enucleation in dentigerous cysts. Sections taken from paraffined block of 12 cases of dentigerous cyst and 12 cases of dental follicle were stained with MIB-1antibody, using immunohistochemical method. The observing of all of the stained sections was done according to Hscore gradation and a degree of staining intensity of epithelial cells and the percent of stained epithelial cells were considered. Then the aggregate these two were announced as the final score. The data were analyzed by Mann-Whitney test. The expression of MIB-1 in dentigerous cyst was greater than dental follicle (P<0.001). This difference was significant for the percentage of stained epithelial cells (P=0.001) and it was greater in dentigerous cyst. The expression of MIB-1 in dentigerous cyst was greater than dental follicle. This difference may are attributed to the capability of neoplastic changes and ability of proliferation in epithelium layer of dentigerous cyst and different clinical behavior of dentigerous cyst.