جستجوی مقالات مرتبط با کلیدواژه « garlic extract » در نشریات گروه « پزشکی »

This study aimed to determine the effect of garlic consumption and endurance training on the serum levels of some pro‑inflammatory and anti‑inflammatory cytokines in female mice with breast cancer.

This study is an experimental research randomly conducted on 32 female BALB/c mice divided into 4 equal groups (N = 8), including: Cancer Control (CC), Garlic Supplementation (GS), Endurance Training (ET), Endurance Training + Garlic Supplementation (ET + GS). One million cancerous cells were injected to all mice’s upper right thigh using the subcutaneous injection method. Exercise groups performed endurance training for 8 weeks (5 days a week .(Garlic supplement groups received 1 ml of the garlic extract orally per kilogram of body weight. The control groups ‑were not given any task, activity or exercise during the research. At the end of the research, all the mice were anesthetized, and their blood samples were collected.

The period of 8‑week simultaneous endurance exercise and consumption of garlic supplement significantly decreased the serum level of interleukin‑6 (F = 75 P = 0.00), interleukin‑8 (F = 97.9 P = 0.00), and interleukin‑17 (F = 95.7 P = 0.00), and increased the serum level of interleukin‑10 (F = 50.4 P = 0.00).

Along with other existing methods, reduction of inflammatory factors, endurance exercises and consumption of garlic supplement have been proved to be an extremely effective treatment for breast cancer patients.

 Retinopathy is a common difficulty in diabetic subjects. Hyperglycemia damages the tissues through stimulation of oxidative stress and inflammation. Since the antioxidant function of garlic has been proven, in the current report the activity of aqueous garlic extract (AGE) upon the oxidative stress and inflammation in the retinal substances of rats with diabetes was investigated.

 24 male Wistar rats were distributed in 4 groups: the healthy rats,  the rats with diabetes (DM2),the garlic- treated rats with diabetes (DM2+AGE), and the garlic- treated healthy rats (AGE). After the treatment was finished, oxidative stress, total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), thiol group (SH), and lipid peroxidation (LPO) were assayed. For the evaluation of inflammation, mRNA and protein levels of transforming growth factor beta-2 (TGF-β2) and interleukin-1 beta (IL-1β) were measured in retinal homogenates using real-time PCR and ELISA, correspondingly.

 In  the DM2 rats, TAC and thiol group diminished (p<0.05 and p<0.001, respectively), whereas TOS and LPO increased (p<0.01 and p<0.001, correspondingly) compared to the control rats. In the DM2+AGE rats TAC and thiol group increased (p<0.01 and p<0.05, correspondingly), whereas TOS and LPO diminished (p<0.05 and p<0.001, correspondingly) compared with DM2 rats. The gene expression and protein concentrations of TGF-β2 and IL-1β increased in  the DM2 rats compared to the healthy group, whereas these parameters decreased in the DM2+AGE rats compared to the untreated rats with diabetes (p<0.001).

 The findings revealed the antioxidant and anti-inflammatory results of garlic extract. Thus, garlic extract could be beneficial for lessening diabetes-induced retinopathy.

This study investigated the effects of an eight-week aerobic exercise program and use of garlic extract on serum atrial natriuretic peptide (ANP) and NT-pro brain natriuretic peptide (BNP) levels in obese hypertensive patients.

A total of 50 male obese hypertensive patients with a mean age of 53 ± 7.6 years were recruited in this study. They were randomly assigned to five groups, including aerobic exercise, garlic extract, aerobic exercise + garlic extract, placebo, and control. The experimental groups were subjected to eight weeks of aerobic exercise (three sessions per week, each session for 35 - 60 min with a maximum heart rate of 50% - 70%) and/or garlic extract supplement (6 g daily). Blood samples were collected before interventions and 48 h after the last exercise session. Statistical analysis of data was performed by dependent t-test and Analysis of Covariance (ANCOVA).

Body weight, body mass index (BMI), systolic blood pressure, diastolic blood pressure, and NT-pro BNP in aerobic exercise, garlic extract, and garlic extract + aerobic exercise reduced significantly compared to control group (P ≤ 0.05). Body weight, BMI, and ANP decreased significantly in aerobic and aerobic + garlic extract groups compared to garlic group (P ≤ 0.001). Moreover, ANP reduced more significantly in aerobic exercise + garlic extract group than in aerobic exercise group (P ≤ 0.05). In addition, NT-pro BNP decreased more significantly in aerobic exercise + garlic extract group than in garlic extract group (P ≤ 0.01).

It seems that both aerobic exercise and garlic extract are able to decrease obesity and hypertension. However, their simultaneous use has no additional effects on hypertension control although it influences the body composition and natriuretic peptides.

Helicobacter pylori infection is one of the most common human infections which have been associated with many upper gasterointestinal complications. Different treatment regimens for Helicobacter pylori eradication have been used. One of these regimes is the quadruple therapy regimen which metronidazole is one of the medications. In recent years several reports on H. pylori resistance to this antibiotic has been presented. This study was performed to compare the effects of garlic and peppermint extract combination with metronidazole in the treatment of Helicobacter pylori infection. In this randomized double blind clinical trial, 142 patients who were eligible for inclusion in study after completing the questionnaire and consent form were randomly divided into two groups, receiving garlic and peppermint extract or metronidazole. Moreover, for both groups the drugs; amoxicillin, omeprazole and bismuth were also administrated. Two weeks after drug administration completion, urease breath test (UBT) was performed and based on the obtained data, the recovery rate in the two groups were compare using SPSS 16 software T-test and Ki squire. The patients mean age was 43.89± 13.37 years. Evaluating the age and sex factors, we found no significant difference between two groups. Results suggest that although the combination of amoxicillin, omeprazole, bismuth plus garlic and peppermint was not successful in the eradication of Helicobacter pylori such as the quadruple therapy, but less than half of cases lead to eradication of Helicobacter pylori infection.