جستجوی مقالات مرتبط با کلیدواژه "hormonal levels" در نشریات گروه "پزشکی"

Sodium metabisulfite (SMB) is a frequently utilized as food preservative. While it is generally acknowledged to be safe, there have been concerns regarding its potential impacts. This study aimed to investigate the effects of sodium metabisulfite on the hormonal levels, ovarian and uterine histology, and oxidative stress markers in female Wistar rats.

Twenty-four adolescent female Wistar rats were randomly allocated into four groups of siz rats each: Group 1 (control) received 0.5mL normal saline; Group 2 was given 100 mg/kg SMB; Group 3 received 300 mg/kg SMB; and Group 4 was administered 500 mg/kg SMB. The administration was done orally over 28 days, followed by euthanasia for tissue collection. Blood samples were collected to assess the serum follicle stimulating hormone (FSH) and luteinizing hormone (LH), while ovary and uterus tissue samples were harvested for malondialdehyde (MDA) assays and histopathology. For histopathology, we used haematoxylin and eosin and periodic acid schiff staining.

The administration of SMB at doses of 300 and 500mg/kg had a notable impact on the hormone levels, particularly FSH and LH. The SMB doses also resulted in disrupted histo-architecture and altered glycogen expression in ovaries and uteri, as observed by histological examinations. Furthermore, SMB at 500mg/kg led to a significant increase in the oxidative stress marker malondialdehyde.

The SMB treatment affected FSH and LH levels, influencing ovarian and uterine structures. Disrupted structure and raised oxidative stress imply reproductive health risks. Further research is needed, including the effects of SMB on glycogen and FSH status.

PCOS (polycystic ovary syndrome) is the most common endocrine and metabolic disorder characterized by amenorrhea, hyper androgens, hirsutism, chronic anovulation and infertility. The aim of the present study was determining the effects of ginger extract, and 6-gingerol on hormonal levels and ovarian follicles in induced PCOS rats, and comparing the ameliorating effects of these two substances for treatment of PCOS.
In this experimental research, 42 adult female Wistar rats weighting between 160 g-180 g were divided into six groups of 7 animals. PCOS control that received no injection. PCOS received intraperitoneal injections of 100 mg/kg of ginger extract (for 28 days). Statistical analyses with SPSS, one-way ANOVA, T-test and Duncan test were used to compare groups.
In comparison with PCOS control, the treatment of PCOS rats with ginger extract (100 and 200 mg/kg) and 6-gingerol (200 and 400 µg/kg) led to significant decrease in LH levels. There was a decrease in FSH levels, but the significant one was only in the 6-gingerol treated group (400 µg/kg). In PCOS treated groups with ginger extract and 6-gingerol, the serum levels of estradiol decreased significantly compared to control and PCOS control groups (P 6-gingerol and ginger extract may be a useful treatment for improving the PCOS through reduction of estrogen, testosterone, LH and FSH, and improvement of ovulation. In fact, because of anti-inflammatory and antioxidant properties of ginger components, especially 6-gingerol, they can cause to improve PCOS.

PCOS (polycystic ovary syndrome) is the most common endocrine and metabolic disorder characterized by amenorrhea, hyper androgens, hirsutism, chronic anovulation and infertility. The aim of the present study was determining the effects of ginger extract, and 6-gingerol on hormonal levels and ovarian follicles in induced PCOS rats, and comparing the ameliorating effects of these two substances for treatment of PCOS.
In this experimental research, 42 adult female Wistar rats weighting between 160 g-180 g were divided into six groups of 7 animals. PCOS control that received no injection. PCOS received intraperitoneal injections of 100 mg/kg of ginger extract (for 28 days). Statistical analyses with SPSS, one-way ANOVA, T-test and Duncan test were used to compare groups.
In comparison with PCOS control, the treatment of PCOS rats with ginger extract (100 and 200 mg/kg) and 6-gingerol (200 and 400 µg/kg) led to significant decrease in LH levels. There was a decrease in FSH levels, but the significant one was only in the 6-gingerol treated group (400 µg/kg). In PCOS treated groups with ginger extract and 6-gingerol, the serum levels of estradiol decreased significantly compared to control and PCOS control groups (P 6-gingerol and ginger extract may be a useful treatment for improving the PCOS through reduction of estrogen, testosterone, LH and FSH, and improvement of ovulation. In fact, because of anti-inflammatory and antioxidant properties of ginger components, especially 6-gingerol, they can cause to improve PCOS.

Hypercoagulable state is a common serious problem in patients with end‑stage renal disease (ESRD). ESRD patients are in a condition of chronic inflammation. An increased level of E‑selectin, “a key adhesion molecule that regulates leukocyte bindings to endothelium at damaged sites,” accompanies the higher risk of inflammation in ESRD patients. We aimed to investigate the possible correlation among E‑selectin as an adhesion molecule, coagulation factors, and inflammatory factors in children with ESRD.

Thirty‑five child patients with ESRD who had been on regular dialysis treatment were registered in our study. Nighteen sex‑ and age‑matched healthy volunteers were used as the control group. Laboratory tests were requested for the evaluation of hematological and biochemical parameters, and parathyroid hormone (PTH), and for coagulation state; fibrinogen, protein C, and protein S were measured. The enzyme‑linked immunosorbent assay (ELISA) (Biomerica, CA, and IDS, UK). for serum E‑selectin assay was provided by R and D Systems (Abingdon, UK).

Hemoglubolin (Hb), blood urea nitrogen (BUN), creatinine, calcium, PTH, triglyceride (TG) concentrations in serum as well as E‑selectin showed significant difference between the two study groups, as indeed was expected. Serum E‑selectin was significantly higher (P value = 0.033) in dialysis patients than in healthy subjects. E‑selectin was positively correlated only with phosphorus in ESRD children (r = 0.398, P = 0.018). No association was found for other parameters.

Although in our study circulating E‑selectin concentration “as an inflammatory maker” is independently positively associated with limited blood markers, for better evaluation, well‑designed cohort studies should be examined in ESRD children.