Association of E‑selectin with hematological, hormonal levels and plasma proteins in children with end stage renal disease

Hypercoagulable state is a common serious problem in patients with end‑stage renal disease (ESRD). ESRD patients are in a condition of chronic inflammation. An increased level of E‑selectin, “a key adhesion molecule that regulates leukocyte bindings to endothelium at damaged sites,” accompanies the higher risk of inflammation in ESRD patients. We aimed to investigate the possible correlation among E‑selectin as an adhesion molecule, coagulation factors, and inflammatory factors in children with ESRD.

Thirty‑five child patients with ESRD who had been on regular dialysis treatment were registered in our study. Nighteen sex‑ and age‑matched healthy volunteers were used as the control group. Laboratory tests were requested for the evaluation of hematological and biochemical parameters, and parathyroid hormone (PTH), and for coagulation state; fibrinogen, protein C, and protein S were measured. The enzyme‑linked immunosorbent assay (ELISA) (Biomerica, CA, and IDS, UK). for serum E‑selectin assay was provided by R and D Systems (Abingdon, UK).

Hemoglubolin (Hb), blood urea nitrogen (BUN), creatinine, calcium, PTH, triglyceride (TG) concentrations in serum as well as E‑selectin showed significant difference between the two study groups, as indeed was expected. Serum E‑selectin was significantly higher (P value = 0.033) in dialysis patients than in healthy subjects. E‑selectin was positively correlated only with phosphorus in ESRD children (r = 0.398, P = 0.018). No association was found for other parameters.

Although in our study circulating E‑selectin concentration “as an inflammatory maker” is independently positively associated with limited blood markers, for better evaluation, well‑designed cohort studies should be examined in ESRD children.