جستجوی مقالات مرتبط با کلیدواژه "intestinal transit" در نشریات گروه "پزشکی"

The polyherbal Wattana formula (WNF) has been used in traditional practice for over 30 years to promote health and prevent age-related issues. However, no scientific evidence supports its efficacy, including its impact on the gastrointestinal system in older individuals. This study examined the effects of WNF on intestinal transit, body weight, and food intake in Wistar rats that received oral WNF at doses of 100, 300, or 1000 mg/kg for 14 days. Following treatment, the small intestine was isolated, and intestinal transit was assessed via charcoal meal travel distance. Compared to the vehicle, 1000 mg/kg WNF significantly reduced intestinal transit in the charcoal meal test and decreased body weight. Additionally, 600 µg/mL WNF extract impeded acetylcholine-induced ileum smooth muscle contraction ex vivo. WNF at all doses demonstrated no effects on food intake. Our findings suggest that WNF may have potential antidiarrheal effects and benefits in weight management and abdominal spasm reduction.

Mentha longifolia L. (Lamiaceae) is an annual herb that is used in the Iranian traditional medicine for treating stomach and intestinal disorders. The purpose of this study was to determine the protective effect of M. longifolia on experimental diarrhea in a rat model. The antidiarrheal activity of essential oil of M. longifolia (20-80 mg/kg) was investigated against castor oil-induced diarrhea in rats using loperamide as the standard reference drug. In acute toxicity evaluation, rats were orally administrated with single dose of EOML at doses ranging from 10 to 1000 mg/kg. EOML caused a significant (p<0.05) and dose-dependent decrease of gastrointestinal transit, nevertheless, it could not block the inhibitory effect of atropine (0.1 mg/kg). EOML at oral doses of 20 and 80 mg/kg protected the animals against castor oil-induced diarrhea significantly (p<0.05). EOML decreased the intestinal fluid accumulation as indicated by the significantly (pp<0.001) decrease compared to control. The oral LD50 of EOML was found to be 470 mg/kg in rat. Since the inhibition of intestinal hyperactivity and hypersecretory are the bases of the treatment of diarrhea, results obtained in the present study suggest that EOML is endowed with antidiarrheal activity. EOML is moderately toxic for oral medication.