Effect of Hydro-Alcoholic Extract of Glycyrrhiza Glabra on Experimental Diarrhea in Mice

Diarrhea, characterized by increased defecation of wet stool and abdominal pains, is of great importance in public health and is one of the most common causes of morbidity and mortality in children worldwide. In the present study, the effect of Glycyrrhiza glabra as a native medicinal plant on diarrhea was investigated.
Material and The effect of hydro-alcoholic extract of G. glabra (HEGG) on small intestinal transit was studied in overnight fasted mice (23-28 g). The antidiarrheal activity of extract was evaluated against castor oil induced diarrhea. Further, the effect of extract on castor oil–induced intestinal transit, and enteropooling at the different doses (50 - 200 mg/kg) were evaluated. Loperamide was used as the positive control.
HEGG significantly (p These findings suggest that the hydro-alcoholic extract of G. glabra roots may contain some biologically active ingredients possessing antidiarrhea properties due to inhibition of gastrointestinal propulsion and fluid secretion.