جستجوی مقالات مرتبط با کلیدواژه « ipth » در نشریات گروه « پزشکی »
-
BackgroundThere are some uncertainties among the risk factors of vascular calcification in the hemodialysis patients. This study was planned to examine the association between abdominal aortic calcification and concerned biochemical parameters in hemodialysis patients.MethodsIn this cross- sectional study, 84 stable hemodialysis patients admitted on hemodialysis section of Shahid Beheshti Hospital in 2013 were enrolled after obtaining informed consent. Pre-dialysis venous blood samples were taken from patients to determine the amount of intact parathyroid hormone (iPTH), alkaline phosphatase (Alk.P), C - reactive protein (CRP), calcium (Ca) and phosphorus (P). Patients underwent abdominal CT scanning and ACI (ACI) was calculated. Statistical analysis was performed using SPSS Version 20. Chi-square, Kruskal Wallis and One Way ANOVA tests were used. P-values < 0.05 were considered significant.ResultsThe average age of participants was 50.15±17.03 years (18-83 y/o).A statistically significant correlation was observed between ACI and ALK-P serum levels (p=0.01). It was found that ACI had a significant relationship with phosphorus in women (p=0.01). ALK-P serum levels in men also had a significant relationship with ACI (p=0.02). In addition, there was a significant correlation between ACI and history of cerebro-cardiovascular disease and also duration of dialysis (p=0.004 and 0.0001, respectively).ConclusionsIn patients with longer duration of dialysis, and patients with a history of cardiovascular and cerebrovascular events, ACI levels were significantly higher. ALK-P and phosphorus were correlated with aortic calcification in males and females respectively. No significant correlation was found between iPTH serum levels and aortic calcification.Keywords: Dialysis, iPTH, Ca, P, Alk.P, vascular calcification, cardiovascular disease}
-
BackgroundSecondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD) leading high mortality and even long-term morbidity. SHPT is manifested by elevation of parathyroid hormone (PTH) and accurate determining the level of serum PTH is very essential for early diagnosis of SHPT secondary to CKD. It is very important to match the values obtained for intact parathormone (iPTH) and 1 84 PTH with the minimized measurement bias.ObjectivesThe present study aimed to first determine the agreement value between the iPTH and 1 84 PTH measures in patients with hyperparathyroidism secondary to endstage renal disease under chronic hemodialysis. Then, we attempted to determine the best cutoff values for these two measurements for detecting SHPT in such patients.
Patients andMethodsThis cross-sectional study was conducted on hemodialysis patients. The value of study biomarkers including iPTH and 1 84 PTH was assessed.ResultsA strong positive association was revealed between the two indicators of iPTH and 1-84 PTH (r = 0.800, PConclusionsThe measurement of both iPTH and 1-84 PTH is valuable for predicting hyperparathyroidism secondary to CKD, but according to lower cost and comparableeffectiveness of iPTH measurement, this assay may be comparable to 1-84 PTH to predict this consequence.Keywords: Intact parathormone, iPTH, 1-84 PTH, ESRD, Hemodialysis, Bio-active, Chronic kidney disease} -
زمینه و هدفیکی از عوامل عمده مرگ و میر در بیماران دیالیزی بیماری قلبی عروقی می باشد که تقریبا شیوع آن در این بیماران به میزان 30-10 برابر جمعیت عمومی تخمین زده می شود. تعدادی از ریسک فاکتورها برای کلسیفیکاسیون شناخته شده اند که شامل هیپرکلسمی و هیپرفسفاتمی، افزایش هورمون پاراتیرویید iPTH))، افزایش پروتئین واکنشی C(CRP) و دیس لیپیدمی هستند.
مواد و روش کاراز بین بیماران دیالیزی مراجعه کننده به مرکز آموزشی درمانی بیمارستان امام علی (ع) بجنورد، تعداد 30 نفر بیمار دیالیزی و 30 فرد سالم را انتخاب کردیم. از تمامی افراد ml 5 خون گرفته شد، و آزمایشات هورمون پاراتیروئید (iPTH) و پروتئین واکنشی C(hs-CRP) به روش الیزا (Enzyme-Linked Immuno Sorbent Assay) و آزمایشات LDL، کلسیم، فسفر، آلبومین، اوره و کراتی نین به روش رنگ سنجی انجام شد.یافته هاپس از مقایسه هورمون پاراتیروئید (iPTH)، میانگین LDL، ضریب کلسیم-فسفر و سطح hs-CRP بین بیماران و گروه کنترل مشاهده شد که تمامی آنها در گروه بیمار به صورت معنی داری بیشتر از گروه کنترل بود. (001/0 p <) همچنین وجودارتباط معنی دار بین گروه (داشتن بیماری) و افزایش ریسک فاکتورهای کلسیفیکاسیون عروقی مشاهده شد.نتیجه گیریمطالعه حاضر افزایش میزان سطح سرمی هورمون پاراتورمون، پروتئین CRP، ضریب Ca*P و LDL را به عنوان فاکتورهای موثر در آترواسکلروزیس در بیماران دیالیزی، نشان می دهد.
کلید واژگان: همودیالیز, آترواسکلروزیس, iPTH, hs, CRP}Background and ObjectivesOne of the major causes of morbidity and mortality in dialysis patient is cardiovascular disease.The prevalence of cardiovascular diseases is estimated to be between 10 to 30 times higher than general population. Some of the known risk factors for calcification are hypetcalcemia and hyperphosphatemia, increased parathyroid hormone(iPTH), increased CRP and dyslipidemia.Materials And MethodsWe selected 30 dialysis patients and 30 healthy persons among persons admitted to the Imam Ali’s hospital of Bojnurd. 5 ml blood was obtained from all subjects. Parathyroid hormone(iPTH) and hs-CRP were measured with ELISA (Enzyme-Linked Immuno Sorbent Assay) reader. Other biochemical factors were measured with autoanalyser.Resultsit was found that Parathyroid hormone (iPTH), mean LDL, calcium-phosphorus products and hs-CRP, between patient group and control group, were significantly different (p<0.001). We also found significant direct relationship between the disease and increased risk factors for vascular calcification.ConclusionThese results support a role for serum iPTH, hs-CRP, ca*P ratio and LDL level as risk factors for cardiovascular disease in hemodialysis patients.Keywords: Hemodialysis, atherosclerosis, iPTH, hs, CRP}
نکته
- نتایج بر اساس تاریخ انتشار مرتب شدهاند.
- کلیدواژه مورد نظر شما تنها در فیلد کلیدواژگان مقالات جستجو شدهاست. به منظور حذف نتایج غیر مرتبط، جستجو تنها در مقالات مجلاتی انجام شده که با مجله ماخذ هم موضوع هستند.
- در صورتی که میخواهید جستجو را در همه موضوعات و با شرایط دیگر تکرار کنید به صفحه جستجوی پیشرفته مجلات مراجعه کنید.