جستجوی مقالات مرتبط با کلیدواژه « modern wound dressing » در نشریات گروه « پزشکی »

Bacterial nanocellulose as a natural hydrogel with unique properties such as high biocompatibility, and non-toxicity has been investigated as a modern dressing in recent years. Accordingly, this research aimed to improve the physical and chemical properties of this biopolymer for biomedical uses by eco-printing clove plant on bacterial cellulose.

For this purpose, the purified layers of bacterial nanocellulose were printed using different amounts of clove in an eco-print method, and consequently, the properties were investigated with ATR-FTIR, XRD, FEESEM, hydrophilicity, and antibacterial activity tests.

The characterization tests confirmed the chemical nature, crystal structure and nanofibrous substrate of bacterial cellulose. Also, the eco-print process did not have a negative effect on the surface hydrophilic properties of the finished samples, and in addition, the water absorption capacity of the sample treated with 10 grams of clove plant was increased by two times compared to the untreated sample. Additionally, all the samples showed antibacterial properties against two Gram-negative (Escherichia coli) and positive (Staphylococcus aureus) bacteria, while increasing the amount of clove active substance on the samples intensified the antimicrobial properties of the layers. Accordingly, the treated samples with 10 gr of clove resulted in the formation of a 30-mm diameter inhibition zone for both bacteria mentioned above.

Based on the findings of this research, it can be concluded that the bacterial nanocellulose treated with clove plant has a high capacity as a modern environmentally friendly wound dressing.

Nanomicrobial cellulose is an important biopolymer with a three-dimensional structure that is produced by some microorganisms and has been widely used in medicine. One of the unique properties of microbial cellulose is its very high water absorption, which can be used to produce modern wound dressings. But after drying, it’s three-dimensional structure collapses and the amount of water reabsorption decreases. Accordingly, the aim of this project was to preserve the three-dimensional structure of nanomicrobial cellulose by networking it and improving the water reabsorption properties of this biopolymer. In addition, the cell viability, proliferation, and cell growth of the modified structure and untreated microbial cellulose were also studied.

In this study, microbial cellulose was produced, purified, and neutralized using stationary culture. The samples were then treated with different concentrations of citric acid/sodium hypophosphite and crosslinked. Finally, the characteristics of treated and raw samples were studied by various tests including ATR-FTIR, MTT, SEM, water absorption and in vitro and in vitro tests.

According to the results, it was found that the cross-linking operation prevents the collapse of the structure and not only does not cause toxicity, but in addition to increasing water uptake, it also increases viability, adhesion, and cell proliferation in the modified cellulose.

Cross-linked nanomicrobial cellulose has high potential as a modern wound dressing.