جستجوی مقالات مرتبط با کلیدواژه « non » در نشریات گروه « پزشکی »

 Non-alcoholic fatty liver disease is a condition in which triglycerides accumulate in liver cells of individuals who do not have a history of alcohol use or use alcohol at a low rate. The aim of the current study was to investigate the effect of alcoholic extracts of St. John's wort and borage plants individually and in combination on non-alcoholic fatty liver in Wistar rats. These two plants were selected due to their innovation and high antioxidant characteristics.

 In the present experimental laboratory intervention study, 70 male Wistar rats were randomly divided into 7 groups of 10, and 10 mice were randomly assigned as the negative control group and the rest were treated with a high-fat diet. Next, 21 days after the onset of a high fat diet and fatty liver, they began to be treated with an alcoholic extract of Silybum marianum and Eryngium and kept for 2 months individually and combined in two doses of at least 200 and a maximum of 400 mg in kg. At the end of the treatment period in 1398 and to evaluate the level of concentrations of unsaturated fatty acids (NEFA), non-esterified fatty acids (BHB: hydroxybutyrate-Beta), alanine aminotransferase (ALT), aspartate amino trans (AST) Aspartate aminotransferase, and gamma glutamyl transferase (GGT) blood samples were taken and the data were analyzed. The findings were analyzed using SPSS, version 24. The results were compared using one-way analysis of variance statistical test at 95% probability level and the significance level of 0.05.

 The results showed that NEFA, BHBA, ALT, AST, and GGT levels in the treated groups of alcoholic extract of Silybum marianum and Eryngium combination and single effect on fatty liver were more than those in the control group and positive control group (P <0.05). The amounts of AST in the control and positive, the negative, and combined control groups were 145.4 ± 9.1, 114 ± 11.4, and 136.1 ± 2.9, respectively.

 It seems that thistle and buckthorn can be used to treat non-alcoholic fatty liver disease, which of course requires clinical trials in livestock, which improves the amount of liver enzymes due to the effect of these plants on liver tissue and improving the amount of related enzymes. Therefore, these plants can be used in future research on livestock and their effects on improving liver enzymes and protecting liver tissue.

Fatty liver disease can result in liver damage along with viral hepatitis, and accelerated disease progression can result in liver tissue fibrosis and liver damage. Aerobic training can reduce the level of liver enzymes (Alp, ALT, and AST) in order for possible treatment of fatty liver disease with aerobic exercise. The present study was performed to assess the effects of Aerobic training on NAFLD.
The present study was a randomized control trial that was performed on 24 obese children (7 to 11 age) with NAFLD, that were divided randomly into two groups (control and experimental). Aerobic exercise was carried out for eight weeks for the experimental group. Before and after the training period, measurements of liver enzyme levels (ALP, ALT, and AST) and liver ultrasound was done. To analyze the data, independent-samples T testing was used.
The results showed that performing aerobic training reduced the levels of liver enzymes ALT (p=0.007), AST (p=0.024), and ALP (p=0.048) in the experimental group significantly.
Aerobic training is recommended as a non-drug treatment for fatty liver disease.

Patients with low back pain like other chronic diseases, may experience psychological symptoms in addition to physical symptoms which leads to the exacerbation of the condition of these patients and reduce their quality of life. Due to lack of clinical studies in this field, this study was conducted to investigate the relationship between pain and severity of depression and anxiety in patients with nonspecific chronic low back pain.
This analytic- descriptive study was performed on 250 patients with nonspecific low back pain referring to the orthopedic clinic in Shahrekord selected by convenience sampling. Demographic questionnaire, visual analogue scale of pain, Beck Depression Inventory and Beck Anxiety Inventory were used to collect the patient’s information, pain severity, anxiety and depression. Stata software 14 was used for data analysis.
Mean ± SD of pain in women was 4.6±1.21 and higher than in men (4.1±1.25). Pain severity showed a significant difference between the groups of patients with different levels of anxiety and depression (P Patients with nonspecific chronic low back pain experience higher level of pain with increasing severity of depression and anxiety. It is necessary in treatment of patients with nonspecific low back pain to pay attention to their psychological dimensions in addition to treating physical problems to reduce pain, and take action to relieve for the modulation of anxiety, depression and quality of life in these patients.

Low Back Pain (LBP) is one of the most common skeletal disorders, with an incidence possibility of up to 80% during one's life. Before planning a rehabilitation program, an accurate evaluation seems to be necessary in people with LBP. With regard to the kinetic chain of human body, any problem or dysfunction in any part of the chain can cause abnormal function in other parts. Abnormal hip kinematics and impaired hip muscle performance have been associated with LBP. So, the purpose of the current study was to compare electric activity ratio of gluteal muscles to tensor fascia lata in males with and without non-specific chronic LBP.
A total of 15 healthy males and 15 males with non-specific chronic LBP participated in the present semi-experimental study. Electromyography signals were obtained from the gluteus medius, superior gluteus maximus, and TFL muscles at 1000 Hz frequency as participants performed some selected exercises and the gluteal-to-TFL muscle activation indices were calculated. Repeated measures analysis of variance and independent t-test were run for data analysis.
The results of the present study demonstrated that, compared with the low back pain group, in launch, squat, hip abduction, clam in side lying, lateral step down, hip extension with extend knee, hip extension with flexed knee, one-side bridge, two-side bridge, and cutting maneuver with elastic resistance, gluteal muscles were significantly more active in healthy group (P The result of the present study shows that the electromyography activity index differs between the gluteal muscles and the tensor fascia lata in people with non-specific chronic LBP and healthy people. In order to plan rehabilitation exercise, the clam in side lying, cutting maneuver with resistance elastic, unilateral, and bilateral bridge exercises can be suggested to people with LBP, with the exception of lunch and squat exercises.

Coronary Artery Disease (CAD) caused by atherosclerosis, Studies have shown that there are a number of factors which are closely related to the development and progression of CAD that include Cellular binding molecules like Plasminogen Activator Inhibitor-1 (PAI-1), multiple cardiac risk factors and hemostasis. In the present study we made an attempt to evaluate the association of PAI-1 4G/4G polymorphism and fibrinolysis markers example PAI-1 with CAD.
In this study, 140 individual, including 70 subjects as patient group and 70 subjects in the control group were considered. Blood samples were obtained from all participants, genomic DNA was extracted and the 4G/4G polymorphism of PAI-1 was amplified using specific primers. Polymorphism in the -675 position in promoter of PAI-1 was detected by PCR-RFLP method. Serum levels of PAI-1 in the samples were measured by ELISA.
Level of PAI-1 serum was significantly different between the two groups. PAI-1 genotype distribution in this case is the frequency of genotype 4G/4G in the patient group compared with the control group had higher. PAI-1 in patients who had genotype 4G, have a higher level compared to homozygous 5G (p-value=0.01). Significant differences between serum level of PAI-1 and PAI-1 gene polymorphism with the risk of CAD was observed.
The 4G/4G polymorphism of PAI-1 gene is a useful marker for fibrinolytic activity. This polymorphism due to increased in plasma level of PAI-1 which causes defects in fibrinolytic activity so increasing the occurrence of cardiovascular diseases.

Non-alcoholic fatty liver is one of the most common diseases. Nutrition and exercise are recommended for the patients with this disease, and chicory is considered due to its protective effects on the liver. Therefore, the aim of the present study was to investigate the effect of chicory extract along with treadmill walking on the hepatic transaminases levels and tissue changes in rats with non-alcoholic fatty liver disease.
In this experimental study, 56 mature male rats were divided into control (without treatment), sham (treatment with high-fat diet 10 ml/kg) and 5 experimental groups receiving high-fat diet (10 ml/kg) with 200 and 100 mg/kg chicory extract alone and with treadmill walking. Chicory was administered as gavage in 28 consecutive days. At the end, after anesthetizing the animals and collecting blood from their hearts the Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline phosphatase (ALP) enzymes were measured. The their livers were removed and after preparing the tissue sections, the results of hepatic enzymes measurements were analyzed by ANOVA and Duncan tests and P≤0.05 was considered significant.
The results showed that high-fat diet increased AST, ALT and ALP enzymes and hepatic tissue damage compared to the control group at p The results showed that high-fat diet increased the levels of ALT, AST and ALP, and hepatic tissue damage. Treadmill walking and chicory extract alone and together reduced the above enzymes and improved the hepatic tissue structure.

Although previous investigations have shown that some dietary components can be associated with non-alcoholic fatty liver disease (NAFLD), few studies have investigated the association between fast food intake and this disease. The aim of this case-control study was to examine the relationship between fast food intake and NAFLD in male adults.
This study was conducted on 100 NAFLD cases and 300 age-matched normal controls. Total data were collected using a 147-item semi-quantitative food frequency questionnaire (FFQ) and physical activity questionaire. Height and weight were measured by standard methods. Data were analyzed using chi-square, t tests and logistic regression model and P Mean fast food consumption in cases were higher than controls (19.5±7.3 vs 10.5±4.2 gr/day, respectively). Higher intake of fast foods was significantly associated with higher intakes of energy, protein, total fat, saturated fatty acids, cholesterol, cole, artificial juices and red meats and lower intakes of fruits, vegetables, legumes and diary products. A higher fast food intake was associated with a higher risk of NAFLD (OR, 3.83; 95%, CI 1.84-7.97; P There was a significant positive relationship between fast food intake and NAFLD in males, emphasizing the need for raising more awareness among individuals on the possible complications of fast food consumption, to decrease their consumption and reduce risk of disease.