جستجوی مقالات مرتبط با کلیدواژه "ocd" در نشریات گروه "پزشکی"

Irritable bowel syndrome (IBS) might be associated with psychiatric disorders such as obsessive-compulsive disorder (OCD). This meta-analysis was conducted to compare the rate of OCD among patients with IBS and otherwise healthy controls.

This study was conducted using a meta-analysis approach. International databases including PubMed, Web of Science, and Scopus, as well as the Google Scholar search engine were searched from 1985 to August 2020 to find the related studies. The standardized mean difference (SMD) of OCD between case and control groups was calculated and pooled by using a random-effects model. In addition, meta-regression and sub-group analysis were performed to identify variables that possibly explain the heterogeneity.

A total of 5167 patients including 1451 IBS patients for case and 3716 for control group entered 15 related studies were included in the analysis. Based on the results of the random effects analysis, the rate of obsessive-compulsive disorder in IBS patients in case group was higher than the control group (Pooled standardized mean difference, 0.76, I2 = 87.8%; 95% CI, 0.54-0.98; P <0.001). Egger’s (P = 0.083) and Begg’s (P = 0.09) tests did not show significant publication bias. Subgroup analysis also revealed that the type of studies and IBS diagnostic criteria were identified as factors affecting heterogeneity.

The present meta-analysis demonstrated that the obsessive-compulsive disorder score in IBS patients was higher than the control group, regardless of subgroup analysis or meta-regression. Due to the significant relationship between these two disorders, psychiatrists and gastroenterologists can provide strategies and techniques for individual or group treatment of obsessive-compulsive disorder in patients with IBS based on the cognitive-behavioral therapy.

Obsessive-compulsive disorder (OCD) is a severe psychological disorder that can be very disabling. Recent increasing neuroscientific data about OCD has provided important evidence that has started to change our knowledge about treatment. This paper offers an applied perspective of neuroscience on diagnosis and treatment preparation for people with OCD disease. The main aim is to enhance clinician-researcher communication to promote the conversion of developments in neuroscience research into better treatment for patients with OCD.

A PubMed search was performed using the keywords “obsessive-compulsive disorder”, “neuroimaging methods”, “neuroscience”, and “neurological treatment”. The search provided sufficient articles published in peer-reviewed journals from 1995 to 2021. The data were obtained from these various sources and were included in this review.

The advancement of neurotherapeutic techniques targeting the cortico-striatal-thalamo-cortical (CSTC) circuit is the subject of a circuit dysregulation system. Also, according to neuroimaging studies, reductions in D2 receptors (about -18%), GABAA receptors (-15%), and cingulate 5-HT1A receptors (-18%) in patients with OCD were reported compared with healthy controls.

The result suggests that DA, 5-HT, and GABA have considerable roles in anxiety- and compulsion-related disorders such as OCD. For patients with OCD, these core neuroscience themes collectively guide formulation and clinical preparation.

Handwashing is now considered as one of the best safety measures to prevent COVID-19 infection. The effect of excessive handwashing for health on OCD patients who are already having washing compulsion is not known. Furthermore, the fear of contamination of COVID-19 in patients who already have obsession of contamination is not known. This study aims to evaluate the effect of COVID-19 on OCD patients.

Phone interviews were done with 84 patients previously diagnosed with obsession of contamination and compulsive washing. Yale Brown Obsessive Compulsive Scale was used and the scores of the participants were compared to their prepandemic scores.

Only 5 patients (6%) had exacerbation of symptoms after the COVID-19 pandemic. Most of the patients did not report any deterioration of symptoms due to the pandemic.

Handwashing protocol does not aggravate the washing compulsion of patients. Similarly, the fear of infection with COVID-19 does not increase their fear of contamination.

Although some surgical techniques have been described for the operative treatment of unstableOsteochondritis dissecans (OCD) of the knee, outcomes are variable and are not satisfying totally. The aim of thepresent study is to evaluate the outcomes of autogenous osteochondral grafting for OCD of the knee.

In a case series study, from June 2014 to July 2015, 16 patients with stage II-IV OCD (International CartilageRepair Society (ICRS)) of the femoral condyle were investigated. Surgical intervention considered in cases of stage III(4 cases) and IV (2 cases) and in stage II (10 cases) ones that were nonresponsive to conservative treatment. At theinitial and final visits, the IKDC, Lysholm score and Tegner activity scale were evaluated.

The mean preoperative IKDC score (53.4) increased significantly following surgery (84.3) (P<0.001).Based on the IKDC grading system, before the operation, the knee status was graded as nearly normal, abnormal,and severely abnormal in 4, 10, and 2 patients, respectively. At final post-surgical follow up, 15 normal and 1abnormal knee were documented (P<0.001). The mean Lysholm score increased from 44.3 per operatively to 86.3(P<0.001).Tegner activity score improved from 2.8±1 pre operatively to 5.6 ±2 (P<0.001).

Surgical treatment of unstable OCD using autogenous osteochondral graft shows successful outcomes.In addition to reliable fixation, it can enhance healing and convert an uncontained lesion to contained one appropriatefor autogenous osteochondral grafting with healthy cartilage.Level of evidence: IV

There have been a few studies that examined the association between insight and the clinical symptoms of obsessive-compulsive disorder (OCD) among the Middle Eastern population. The current study aimed to find a relationship between insight, general score and the specific dimensions of OCD among Iranian clinical sample.

The cross-sectional research method was conducted on 108 OCD patients from 18 to 61 years old. Participants were interviewed with a semi-structured interview based on DSM-V, and those who were diagnosed with other psychiatric disorders were excluded. Also, participants filled out some self-report scales including Obsessive-Compulsive Inventory-Revised, Overall Anxiety Severity and Impairment Scale and Beck Depression-II Inventory.

The results showed that poor insight has a relationship with OCD symptoms except for hoarding. Moreover, anxiety was significantly correlated with the severity of OCD.

There are different pathophysiological mechanisms for obsessive- compulsive disorder (OCD) as suggested by the serotonergic, dopaminergic, and glutamatergic hypotheses. The present study aimed at comparing the efficacy and safety of saffron (stigma of Crocus sativus) and fluvoxamine in the treatment of mild to moderate obsessive- compulsive disorder.
In this study, 50 males and females, aged 18 to 60 years, with mild to moderate OCD, participated. The patients were randomly assigned to receive either saffron (30 mg/day, 15 mg twice a day) or fluvoxamine (100 mg/day) for 10 weeks. Using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Adverse Event Checklist, we assessed the patients at baseline, and at the second, fourth, sixth, eighth, and tenth week. Finally, the data were analyzed using general linear repeated measures.
In this study, 46 patients completed the trial. General linear repeated measures demonstrated no significant effect for time-treatment interaction on the Y-BOCS total scores [F (2.42, 106.87) = 0.70, P = 0.52], obsession Y-BOCS subscale scores [F (2.47, 108.87) = 0.77, p = 0.49], and compulsion Y-BOCS subscale scores [F (2.18, 96.06) = 0.25, P = 0.79]. Frequency of adverse events was not significantly different between the 2 groups.
Our findings suggest that saffron is as effective as fluvoxamine in the treatment of patients with mild to moderate OCD.

Since psychological tests such as questionnaire or drawing tests are almost qualitative, their results carry a degree of uncertainty and sometimes subjectivity. The deficiency of all drawing tests is that the assessment is carried out after drawing the objects and lots of information such as pen angle, speed, curvature and pressure are missed through the test. In other words, the psychologists cannot assess their patients while running the tests. One of the famous drawing tests to measure the degree of Obsession Compulsion Disorder (OCD) is the Bender Gestalt, though its reliability is not promising.
The main objective of this study is to make the Bender Gestalt test quantitative; therefore, an optical pen along with a digital tablet is utilized to preserve the key drawing features of OCD patients during the test.
Among a large population of patients who referred to a special clinic of OCD, 50 under therapy subjects voluntarily took part in this study. In contrast, 50 subjects with no sign of OCD performed the test as a control group. This test contains 9 shapes and the participants were not constraint to draw the shapes in a certain interval of time; consequently, to classify the stream of feature vectors (samples through drawing) Hidden Markov Model (HMM) is employed and its flexibility increased by incorporating the fuzzy technique into its learning scheme.
Applying fuzzy HMM classifier to the data stream of subjects could classify two groups up to 95.2% accuracy, whereas the results by applying the standard HMM resulted in 94.5%. In addition, multi-layer perceptron (MLP), as a strong static classifier, is applied to the features and resulted in 86.6% accuracy.
Applying the pair of T-test to the results implies a significant supremacy of the fuzzy HMM to the standard HMM and MLP classifiers.

The aim of this study was to elucidate efficacy of transdiagnostic cognitive behavior therapy based on Unified Protocol (UP) for reducing symptoms severity of obsessive compulsive disorder (OCD) with co-occurring anxiety and unipolar mood disorders.
From the thirty patients who participated to treatment, twenty four participants were randomly assigned to receive either immediate or delayed treatment. All participants were assessed using both clinician-rated and self-report measures. The immediate or intervention group were received 20 sessions taking one hour TCBT intervention based on UP but delayed group did not receive any intervention. After gathering the data from two groups, the UP was implemented for delayed or control group. Three regular assessment administrated that consisted of pretest, posttest, and a month follow-up (FU).
The UP afforded a very strong effect on diagnostic severity, obsessive compulsive frequency of symptoms, dimensions and total functioning for principal diagnoses from pretreatment to FU. Effect size statistics for assessing treatment gains showed large effects (of 1.49 to 2.64) for heterogonous comorbid disorders that was retained on follow-up. The differences in the proportion of individual achieving responders and high end-state function (HESF) between comorbid diagnoses at post treatment and FU were not statistically significant.
Results from this study provide additional evidence for the efficacy of the UP in the treatment of OCD with co-occurring anxiety and unipolar depressive disorders, and provide additional support for a transdiagnostic approach to the treatment of emotional disorders.

The aim of this study was to compare obsessive-compulsive disorder (OCD) comorbidity in early and late onset bipolar I disorder and to explore the pattern of obsessive symptoms in these two groups. A total of 100 inpatients with early and late bipolar disorder were admitted in the child, adolescent and adult psychiatric ward. They were recruited to the study through convenience sampling. All patients had a current DSM-IV episode based on using K-SADs and SCID. They were evaluated to abut obsessive-compulsive disorder comorbidity using Y-BOCS. Clinical data were compared using multivariate test. Fifty-two percent with early onset versus twenty-eight percent of late onset bipolar cases had a comorbidity of OCD and the difference was significant (p<0.05). Obsessive symptoms in early onset group were more religious, aggressive, sexual and somatic types. Our study showed high comorbidity rate of OCD among patients with early onset bipolar disorder. Future large-scaled prospective studies are required for better understanding of factors related to bipolar and OCD co-occurrence.

The Obsessive Beliefs Questionnaire-44 (OBQ-44), a self-report measure, was developed by the Obsessive Compulsive Cognitions Working Group (OCCWG) to assess beliefs considered relevant in the etiology and maintenance of obsessions and compulsions. The purpose of this study was to evaluate the psychometric properties of the Persian language version of the Obsessive Beliefs Questionnaire (POBQ-44). A sample of 222 medical students from an Iranian university was used to assess the reliability and validity of the POBQ-44. The results indicated five factors: 1) general, 2) perfectionism, certainty, 3) responsibility and threat estimation, 4) importance and control of thoughts, 5) complete performance. Each of these factors was found to have adequate test-retest and internal consistency reliability. Each of the factors was associated with O-C symptoms. In addition, adequate convergent validity was found with a measure of obsessive compulsive symptoms, and discriminate validity was found with measures of depression and anxiety.