جستجوی مقالات مرتبط با کلیدواژه « oliveria decumbens » در نشریات گروه « پزشکی »

Cancer therapy necessitates innovative approaches with enhanced efficacy and reduced side effects. Essential oils have gained attention because of their diverse biological properties and relatively low toxicity. Zataria multiflora essential oil (ZEO) and Oliveria decumbens essential oil (OEO) exhibit promising anti-cancer effects, particularly in modifying oxidative stress and inflammation. Both oils boast complex compositions rich in bioactive compounds, including oxygenated monoterpenes and phenolic compounds like carvacrol and thymol. Hence, this study investigates essential oils’ anti-cancer, anti-oxidant and immunomodulatory effects, focusing on ZEO and OEO.

This review briefly considers the intricate mechanisms of several essential oils, encompassing anti-oxidant, anti-inflammatory and anti-cancer properties. Then the review delves into the multifaceted mechanisms underlying the anti-cancer properties of ZEO and OEO. 

Studies showcase the ability of ZEO and OEO to induce apoptosis in cancer cells through various pathways, such as mitochondrial dysfunction, reactive oxygen species (ROS) generation and DNA damage while sparing normal cells. Our studies further validated the immunomodulatory effects of OEO and ZEO in tumor-bearing mice, resulting in reduced tumor volume. Additionally, this review confirmed the synergistic effect of ZEO when combined with doxorubicin to inhibit cancer cells. 

Some essential oils, such as ZEO and OEO, present promising natural compounds in cancer therapy, offering diverse mechanisms of action targeting various aspects of tumor biology.

Cholestasis is described as a disease in which bile flow from the liver is reduced or stopped, and due to its oxidative effects, irreversible consequences may occur.

Due to the remarkable antioxidant properties of Oliveria decumbens (OD) and the contribution of oxidants to the progression of bile duct ligation (BDL)-induced cholestasis, this research aimed to examine how the OD ethanolic extract affected liver damage and oxidant-antioxidant balance markers in BDL-induced cholestasis.

Forty male Wistar rats weighing 200 - 250 g were used. Cholestasis was induced using the BDL approach. The rats were categorized into four groups: Group 1, sham-control (SC); group 2, cholestatic; group 3, SC + OD; and group 4, cholestatic + OD. A dose of OD ethanolic extract was administered orally (500 mg/kg/day) to rats for seven days. Seven days following surgery, the rats’ blood samples were collected; after sacrifice, a part of the liver tissue was isolated. A histopathological examination was performed, while the rest was stored at -70°C in liquid nitrogen. Heparin-containing tubes were used to gather blood samples. In plasma and hepatic tissue, biochemical tests, histopathological evaluations, and oxidative stress markers staining levels were performed.

Our findings showed that OD could effectively reduce liver injury by reducing the activity of liver function enzymes (AST and ALP). At the same time, it did not affect total bilirubin and protein. Bile duct ligation-induced hepatic markers of protein oxidation (PCO) and reactive nitrogen species (NO) were significantly decreased by OD, and it also promoted liver antioxidant capacity by enhancing superoxide dismutase (SOD) activities. Moreover, OD treatment prevented liver bile duct proliferative changes in histopathologic analysis.

Our study confirmed that OD exerts substantial hepatoprotective activities against BDL-induced cholestasis by improving liver damage markers and regulating oxidative stress. It may be a beneficial therapeutic agent for managing cholestasis. Bioassay-guided isolation and identification of bioactive OD secondary metabolites can further direct the discovery of potential natural-based drug candidates.

Staphylococcus aureus is a pathogenic bacterium that forms biofilms on biotic and abiotic surfaces. Biofilm formation is important for researchers because it increases the risk of food contamination in the food industry, increases the pathogenicity of bacteria, and damages the equipment. The main purpose of this study was to find out the antimicrobial and antibiofilm properties of Oliveria decumbens essential oil (Od-EO) against Staphylococcus aureus.

In this study, the antibacterial and anti-biofilm properties of Od-EO were tested against four strong biofilm producers. S. aureus isolates were obtained from food and humans. The antibacterial properties of Od-EO on planktonic S. aureus were investigated using the disk diffusion method; further, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined. The microtiter plate (MTP) method and slime production evaluation were used to assess the inhibitory effect of Od-EO on S. aureus biofilm formation.

Od-EO indicated strong antimicrobial activity against planktonic S. aureus. After performing tests related to the anti-biofilm activity of Od-EO, it was found that Od-EO significantly reduced slime production and thus inhibited biofilm formation.

Od-EO and its components can be used as a new anti-biofilm agent in medical, dental, and food industry equipment.

Medicinal plants are useful in perfumery, pharmaceutical, and food industries. Recognition of compounds and functional groups of these plants helps to more understand their structure, medicinal and therapeutic applications. Essential oils and extracts are used to recognition structure. One of these spectroscopic methods for identifying functional groups in medicinal plants is Fourier-transform infrared spectroscopy (FTIR) spectroscopy. This study aimed to identify the functional groups of medicinal plants of Oliveria decumbent native to Ilam by the FTIR method. Based on the results obtained, it was determined that this plant includes 15 spectra including groups O-H, C-H, C = O, C = C, N-O, C-O, C-N, and C-I. So, the present study concluded that the Oliveria decumbens possessed strong functional groups.

Leishmaniasis is the main health problem and affects millions of people, especially in developing countries. On the other hand, there is no immunoprophylaxis (vaccination) accessible for the treatment of Leishmania infections and commercial drugs are unsatisfactory. Therefore, there is an effort to find alternative herbal remedies. The objective of the present study was to state the antileishmanial activity of two herbal medicines such as Satureja khuzestanica Jamzad and Oliveria decumbens Vent. leaf extracts on the promastigotes of Leishmania major and Leishmania infantum.

The hydroethanolic extracts of each plant were extracted and their antileishmanial effects evaluated in different concentrations (0–156 μg/ml) and at various hours (24, 48, and 72 h) using colorimetric (3[4, 5dimethylthiazol2yl]2, 5 diphenyltetrazolium bromide) assay. The concentrationresponse curves of tested extracts and glucantime solutions as a reference were designed, and 50% of inhibitory concentration (IC50) values were recorded.

Antileishminal activity of S. khuzestanica, O. decumbens, and glucantime drug on L. major and L. infantum promastigotes were revealed with IC50 values of 4.3 and 5.5 μg/ml for S. khuzestanica, 0.85 and 0.23 μg/ml for O. decumbens, and 40.2 and 18.5 μg/ml for glucantime after 72 h incubation.

These results revealed that compounds from S. khuzestanica and O. decumbens have antileishmania properties that necessary to survey the effects of these extracts on leishmania genus in animal models in the future.