جستجوی مقالات مرتبط با کلیدواژه « pulegone » در نشریات گروه « پزشکی »

Ziziphora tenuir and Teucrium polium belong to the Labiatae family. So far, 25 and 4 species of Ziziphora tenuir have been reported in the world and Iran, respectively, which are used for novel digestive disorders, common cold, depression, and migraine. A total of 200 species of Teucrium polium have been identified in the world, and 12 species exist in Iran. The historical use of this herb dates back to the time of Hippocrates and Galen. The present study aimed to investigate some of phytochemical characteristics of two medicinal species of Ziziphora tenuir and Teucrium polium in Sarbisheh region of South Khorasan Province.

In this in vitro study, the aerial parts of Ziziphora tenuir and Teucrium polium, including leaves, flowers, and flowering branches, were collected from the region at the end of July 2019, and after drying, the samples were distilled using a Clovnjer machine. The identification of the constitutive compounds of the obtained essential oils was performed using GC and GC/MS devices.

The main composition of the essential oil in Ziziphora tenuir in the study area was Pulegone, with 92.55%, including eight types of essential oil composition. The highest amount of effective substances was reported for phenol and antioxidant, while tannin and flavonoid had the lowest amount. 23 essential oil compounds, including Camphor (43.72) and Artemisia alcohol (18.61%) were identified as the highest amounts for Teucrium polium, while Cymene (0.42) and a-Thujone (0.24%) were reported as the lowest amounts. The effective ingredients of Teucrium polium, including Phenol and antioxidant, in contrast with flavonone and flavonoid, were respectively reported as the highest and lowest amounts.

The high amount of Phenol in both species indicated the inhibitory power and is related to the Terpinen compounds in the essential oil of both species. On the other hand, the lower the IC50 value, the higher the inhibition of free radicals and, as a result, the higher the antioxidant property.

The issue of antibiotic resistance is currently being pursued very seriously. One of the drug-resistant bacteria is Pseudomonas aeruginosa. As an opportunistic and important pathogen in human and livestock, this bacterium can be resistant to various antibiotics in different ways. For thisreason, research to obtain antimicrobials from alternative sources such as plants and plant essential oils is considered by many researchers. This study investigated the antimicrobial potentials and therapeutic effects of pulegone in experimental cutaneous pseudomoniasis in goats clinically.

Four two-year-old female goats weighing approximately 45 kg were used. To prepare the P. aeruginosa inoculation site, the right and left chest and the flank on both sides of the animal were shaved to an area of 30 cm2 at each site. After supressing the immune system by injection of dexamethasone, in each place at five points and at each point 0.4 ml of P. aeruginosa suspension, was injected intradermally. After cutaneous pseudomoniasis induction, lesions in the right thoracic region were treated with glycerol-soluble pulegone, lesions in the left thoracic region were treated with gentamicin ointment as standard treatment, and lesions in the right thoracic region were treated daily with glycerol. Lesions in the left flank were not treated as a control group.

The results of this study showed that pulegone, just like gentamicin, treats goat cutaneous pseudomoniasis wounds in nine days and heals them effectively.

 Strangle in the horses is the commonest and the most significant infectious disease. An antibiotic of the first choice, commonly Penicillin, is used for antimicrobial therapy. Due to side effects and resistance against used antibiotics, interest in novel antimicrobial substances from other sources, including herbal medicine as safe agents has been raised. This study evaluated the antibacterial susceptibility profile of Streptococcus equi subsp equi in the confrontation of Trans-cinnamaldehyde, 1, 8 Cineole, and Pulegone on bacterial pathogens isolated from the horse.

 Two hundred clinically isolates were studied by the single disk method to Ampicillin, Ciprofloxacin, Trimethoprim sulfamethoxazole, Gentamicin, Enrofloxacin, Chloramphenicol, Azithromycin, Cefotaxime, Oxytetracycline, Erythromycin, and Penicillin. Paper discs were prepared by impregnation in 10 µL essential oils main compounds (EOMC). The antibacterial activities of Trans-cinnamaldehyde, 1, 8 Cineole, and Pulegone were evaluated by microbroth dilution and disk diffusion methods against isolates of S. equi.

 All the isolates were resistant to Trimethoprim-sulfamethoxazole and Cefotaxime. The maximum growth inhibition zone was related to Oxytetracycline and Ampicillin. The growth inhibition zone diameter was 30 mm, 20 mm, and 26 mm for Trans-cinnamaldehyde, Pulegone, and 1, 8 Cineole, respectively. The results of the Minimum inhibitory concentrations (MICs) and Minimum Bactericidal Concentrations (MBCs) showed that Trans-cinnamaldehyde had the highest antibacterial activity compared to other EOMC against S. equi. This study indicated that Trans-cinnamaldehyde, 1, 8 Cineole, and Pulegone revealed antibacterial properties; therefore, these main constituents of the medicinal plant could be a safe candidate for the new antibacterial products.