جستجوی مقالات مرتبط با کلیدواژه "srebp-1" در نشریات گروه "پزشکی"

Although LXRα and SREBP-1C are involved in lipid metabolism and liver injury, mechanisms of their modulation following exercise and herbal supplement consumption are less investigated. The aim of the present study was to investigate effects of 8 w of aerobic exercise and cinnamon extract on the expression of SREBP-1c and LXRα in the liver tissue of mice fed with fructose.

To carry out the present experimentally practical study, 32 6-w-old male rats with an average weight of 154.66 g ±10.95 and insulin resistant by feeding 10% fructose solution for 5 w were randomly divided into four control (IRC), exercise (IRT), cinnamon extract (IRCi) and exercise-cinnamon extract (IRTCi) groups. The training program was implemented for 8 w with 5 d each week with an intensity of 75–80% VO2max from 10–15 min in the first week to 60 min in the last week. The IRCi and IRTCi groups were injected daily with 200 ml/kg cinnamon extract. After 8 w, rats were sacrificed and the variables were assessed using real-time polymerase chain reaction.

Significant decreases in SREBP-1c expression were seen in IRT (p = 0.032), IRCi (p = 0.045) and IRTCi (p = 0.005) groups, compared to IRC. The expression of LXRα in the IRT (p=0.022), IRCi (p=0.024) and IRTCi (p=0.0001) groups had a significant increase compared to the IRC group. In addition, a significant increase in LXRα expression was observed in IRTCi groups compared to IRT (p=0.048) and IRCi (p=0.044) groups.

Results verified effects of aerobic exercise and cinnamon extract alone and in combination with each other on the expression of genes affecting fat metabolism and lipogenesis as well as greater interactive effects on the LXRα variable. Therefore, it is recommended to use exercises and supplements with caution.

Insulin resistance (IR) is known as the most important cause of Liver Disorders, Which is associated with decreased expression of Peroxisome proliferator-Activated Receptor-alpha (PPAR-α) and increased expression of Sterol regulatory Element Binding Proteins (SREBP-1C) and Carbohydrate response element binding protein (CHREBP) in diabetic type 2 male rats. The aim of this study was to evaluate the effect of eight weeks of aerobic exercise on hepatic PPAR-α , SREBP-1C and CHREBP expression and IR in n diabetic type 2 rat.

In this experimental study, 27 male Wistar mice were randomly divided into three groups of healthy control, diabetic control and diabetic exercise. Medium and progressive aerobic exercise protocol on the treadmill was performed and The trainings lasted 8 weeks and 5 days/week. At the end of the trainings PPAR-α, SREBP-1C and CHREBP expressions were examined via ELISA technique in the liver tissue. One-way Analysis of variance (ANOVA) test were used to compare the groups and the significance level was considered at p < 0.05.

The post-hoc test results indicated a significant reduction in IR between the diabetic control group and aerobic training (P<0.05). Despite a notable increase in hepatic expression, it PPAR-α, SREBP-1C and CHREBP was statistically significant

aerobic exercise for eight weeks improved IR in type 2 diabetic rats. There was a significant difference in the expression of liver proteins between the groups. 

 Consuming a high-fat diet causes obesity, which is one of the hallmarks of metabolic syndrome. The present study aimed to assess the effect of aerobic training and capsaicin supplementation on the expression of lipogenic genes SREBP-1c and FASN in the liver tissue of obese rats

 For this experimental research, 40 eight-week-old male Wistar rats weighing 181.5±2.3 grams were selected as samples. Thereafter, eight rats were fed a normal diet (ND), and 32 rats were fed a high-fat diet (HFD) and randomly assigned to five groups: normal diet, high-fat diet, high-fat diet-training, high-fat diet-capsaicin, and high-fat diet-training-capsaicin. The exercise groups performed an incremental aerobic exercise program (15-25 m/min, 30-60 min/day, five days/week) on a treadmill for eight weeks. Capsaicin (4 mg/kg/day) was taken orally by gavage once a day.

Induction of obesity was associated with increased expression of SREBP-1C (P=0.001) and FASN (P=0.001). It was also revealed that aerobic exercise with capsaicin supplementation significantly decreased SREBP-1C and FASN gene expression in the experimental groups compared to the obese group. Finally, this reduction trend was significant in the combined group compared to the supplement group.

It is possible that the use of capsaicin, along with aerobic physical activity, is an effective strategy to neutralize the markers of hepatic lipogenesis.

Adipose tissue is one of the tissues that affects the process of obesity. The aim of the present study was the effect of eight weeks of high intensity interval training on the expression of 12.13.diHome, SREBP-1 genes and body composition of non-obese rats.working method; In the present study, 18 obese Wistar rats, aged eight weeks and weighing 343.88±42.20 grams, were randomly divided into two groups; high intensity interval training (10 heads) and control (8 heads). The rats of the experimental group performed high intensity interval training with an intensity of 85 to 90% of the maximum speed for eight weeks, five sessions a week, and Real Time-PCR method was used to measure the expression of 12.13.diHome and SREBP-1 genes. Became. Statistical methods of independent t-test and dependent t-test were used to check the statistical data at a significance level of P ≤ 0.05.Results; The results of the present study showed that high intensity interval training led to a significant increase in the expression of the 12.13.diHome gene (P=0.01) and a decrease in the expression of the SREBP-1 gene. The same embryo caused a decrease in the weight (P=0.001) and body mass index (P=0.001) of the rats.conclusion; According to the results of this research, it is suggested to use high intensity interval training that increase intramuscular lipolysis and decrease hepatic lipogenesis; To be used to reduce fat mass