جستجوی مقالات مرتبط با کلیدواژه « tebuconazole » در نشریات گروه « پزشکی »

Tebuconazole is a systemic fungicide whose toxicity has been reported in animals and humans due to direct and indirect exposure. Our study aimed to assess the hepatotoxic effects of tebuconazole at subacute doses in rats.

Tebuconazole was administered by oral gavage at doses of 6, 12, 25, 50, and 100 mg/kg daily. Serum levels of ALT, AST, and ALP were determined. Histopathological analysis was performed using liver sections stained with hematoxylin and eosin. Parameters such as cell inflammation, accumulation of lipid vacuoles, and hepatocyte necrosis were assessed. 

The results showed that the serum levels of AST, ALT, and ALP enzymes elevated in all Tebuconazole doses compared to the control group. This elevation was statistically significant in the 50 and 100 mg/kg groups compared to the control group. Histopathological results revealed the increased necrosis and destruction of hepatocytes and accumulation of lipid vacuoles in the study groups compared to the control group.

The study’s results showed significant hepatotoxic effects at subacute doses of tebuconazole. These results are alarming in the widespread use of tebuconazole as a fungicide. It is recommended to take the necessary precautions, including wearing gloves or a mask.

A 48-year-old man was admitted to our hospital with complaints of productive cough, anorexia, and sweating from two weeks ago. Laboratory studies revealed an increased level of liver enzymes. The work-up of serological markers was negative for both infectious and non-infectious causes of hepatitis. He denied smoking, alcohol consumption, occupational exposures, and illicit drug use. Interestingly, he had a history of contact with an antifungal toxin called tebuconazole about 15 days before admission. In toxicological examinations using gas chromatography with a nitrogen-phosphorus detector, the cause of poisoning was revealed to be fungicide tebuconazole. To confirm the causal relationship between toxin and hepatitis, exposure avoidance and repeated testing were considered. Complete recovery was achieved in all clinical symptoms and laboratory findings. We suggest that tebuconazole-induced hepatitis should be considered in farmers exposed to this fungicide.