جستجوی مقالات مرتبط با کلیدواژه « ایدیوپاتیک » در نشریات گروه « پزشکی »

Short children face many problems throughout their lives. Consumption of growth hormone and the drugs such as Letrozole, Oxandrolone, and Anastrozole can increase the growth of children and adolescents. There is not an overall estimate of the effects of Letrozole, Oxandrolone, and Anastrozole on the growth of children and adolescents with Idiopathic Short Stature (ISS). There are different estimates of the effect of growth hormone and the drugs Letrozole, Oxandrolone, and Anastrozole on growth in children and adolescents with Idiopathic Short Stature. Therefore, the aim of this study was to compare the efficacy of growth hormone, Letrozole, Oxandrolone, Anastrozole, and a combination of growth hormone and aromatase inhibitors on height gain in children and adolescents with idiopathic short stature using meta-analysis method.

Search was done in databases such as; Scopus, Web of Science(ISI), and PubMed using keywords: Idiopathic, Short Stature, Body Height, Aromatase Inhibitors, Growth hormone, Letrozole, Oxandrolone, Anastrozole. Randomized clinical trial studies ,that have investigated the efficacy of growth hormone and aromatase inhibitors on height gain in children and adolescents with short stature, were selected. Height standard deviation score (HSDS) before intervention and after treatment has been used to measure the rate of height increase in various studies. This study was written based on the PRISMA checklist and the heterogeneity of this study was evaluated using the Q statistic and I2 index.

Height increase index (HSDS) was obtained with the use of growth hormone combined with one of the aromatase inhibitors (0.38-3.58=95%CI) (SMD=0.98), with the use of growth hormone (0.62-1.14=95%CI) (SMD=0.88), with the use of Letrozole (0.51-16.51=95%CI) (SMD=0.83), with the use of Oxandrolone (0.99-0.99=95%CI) (SMD=0.56), and with the use of Anastrozole (0.00-0.63=95%CI) (SMD=0.31), which shows that all these drugs have a significant effect on height increase. (P<0.05)

Although the effect of growth hormone on height increase was greater than that of aromatase inhibitors, but according to our results, adding an aromatase inhibitor to growth hormone can increase the effectiveness of it.

Hyperbilirubinemia is a neonatal ubiquitous condition but the role of life style factors and endocrine disrupting chemicals (EDCs) on the incidence of this globally prevalent symptoms remained unclear. This study aimed to determine the role of EDCs and other predisposition factors in this regard.

At first, 120 mothers and infants (60 pairs as control and 60 pairs as cases) were conveniently sampled after delivery and before their discharge. The mothers were interviewed and their case records were reviewed for risk factors for neonatal jaundice using SPSS software 24. We used studentchr('39')s t test for parametric and Chi-square test for non-parametric analysis of variables. Risk factors calculated by Mann-Whitney U test and p- values< 0.05, OR>1 and CI> 1 were considered as significant difference and jaundice risk factors respectively.

Out of different demographical and lifestyle factors including exposure to outdoor and indoor chemicals, extensive exposure to air fresheners (OR=16.319, 95%CI=2.06-129.292, p=0.001) and detergents (OR=4.958, 95%CI=2.074-11.852, p=0.0001) were considered as two major life style predisposing factors of idiopathic hyperbilirubinemia.

According to the results obtained from this study, unhealthy life style and endocrine disrupting chemicals consumption could significantly increase the risk of jaundice but further animal and clinical studies are necessary to find out their direct associations.

Clubfoot occurs in approximately 1 in 1000 live births and is one of the most congenital birth defects. The Non operative technique for the treatment of idiopathic club foot is described by Ponesti as a popular method. Tenotomy is on integral step of this method. The purpose of this study was to evaluation of predictive factors for tonotomy at the initiation of the Ponesti treatment.

In this descriptive cross-sectional study, all patients with idiopathic clubfoot under the age of 6 months who had referred to the orthopedic clinic of Imam Khomeini Hospital in Urmia from April 1 to March 2017, and were treated by pontic method, were included in the study. Parametric statistical tests such as chi-square and t-test were used. The significance level for all tests was below 0.05. All analyzes were performed using SPSS software version 21.

Tenotomies were performed in 39 feet of 52 feet (75%). Of 22 feet with initial Pirani scores ≥ 5.0, 95.5% required a tonotomy. Of 11 feet with an initial scores≤2.5, only 18.2% required a tenotomy. There was a significant difference between the need for tenotomy and severity of the deformity at onset of treatment (P<0.001). Removal of the last cast, there was no significant difference between those that did and did not have a tenotomy (P=0.789). Those that underwent tenotomy did not require more casts. Casting began in the newborn period (≤ 30days) on 34 feet. Tenotomy was not needed in 11 feet. There was a significant difference between the need for tonotomy and age at beginning of treatment (P=0.018).

Tenotomy is not required in all cases. Severity of the deformity at presentation, especially hindfoot contracture and age at the beginning of treatment can predict the need for tenotomy

Idiopathic granulomatous mastitis is an inflammatory disease with unknown etiology. The clinical signs and mammograms of the disease can mimic breast cancer. The present study reports a case of idiopathic granulomatous mastitis in a pregnant woman. A 26-year-old woman, who was 24 weeks pregnant, felt a mass on her left breast. Biopsy of the mass revealed no evidence of malignancy. For treatment, intravenous and oral prednisolone tablets were prescribed during the pregnancy, which was terminated without a problem under normal care.

  Infertility is a reproductive issue that has influenced couples worldwide and caused them psychiatric and emotional troubles. It is believed that mitochondrial proteins play a major role in male infertility. One of the most important of these proteins is UCP2, which consists of more than 10% of mitochondria’s inner membrane proteins. The purpose of this study was to investigate the association of UCP2 45bp ins/del polymorphism with idiopathic male infertility.

In this case-control study, UCP2 polymorphism was investigated in 196 individuals with idiopathic infertility and 278 healthy individuals. UCP2 45bp ins/del genotypes were identified by the polymerase chain reaction (PCR) technique. Also, genotype and allele frequencies in cases and controls were assessed by logistic regression analysis. No association was observed between UCP2 45bp ins/del polymorphism genotypes and risk of idiopathic male infertility, but there was a marginal difference between cases and controls regarding II genotype frequency (P=0.08). Moreover, data analysis showed that I allele had protective effect against idiopathic male infertility (OR: 0.729, 95%CI: 0.54-0.985, P=0.039).

Discussion & In this study, for the first time, we found that the I allele in UCP2 45bp ins/del polymorphism has protective effects against idiopathic male infertility. Further studies with larger sample sizes and different ethnicities are needed to confirm these results.

Male infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Spermatogenic Failure accounts for more than half of male infertility cases. Heat shock proteins (HSPs) are the molecular chaperones that are involved in different developmental stages of spermatogenesis. The current study was planned to investigate the role of HSPA1B rs6457452 genetic variants in male infertility.
Material and This case control study was conducted on 516 subjects consisted of 308 patients with idiopathic male infertility and 208 control subjects. After DNA extraction from peripheral blood, genotype determination was done by Tetra-ARMS PCR method. Logistic regression analysis was used to estimate the association between the polymorphism and male infertility.
A significant difference was observed in genotype distributions between cases and controls. Results showed individuals with TC (OR=1.552, 95%CI: 1.032-2.334, p=0.035) and TT (OR=2.746, 95%CI: 1.153-6.545, p=0.023) genotype had an increased risk of male infertility. Also, there was a significant association between T allele (OR=1.695, 95%CI: 1.220-2.355, p This study showed for the first time that HSPA1B rs6457452 polymorphism is associated with infertility risk in Iranian men and the T allele may act as a dominant allele for increasing the risk of male infertility.

Male infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Despite the methodological advancements, the possible causes of infertility are still unknown for more than 25 percent of cases. Heat shock proteins (HSPs) are the molecular chaperones that are involved in different developmental stages of spermatogenesis. The current study was planned to investigate the role of HSPA1L rs2227956 gene polymorphism in the idiopathic infertility in males.
Material & This case control study was conducted on 342 subjects consisted of 143 patients with idiopathic male infertility and 199 control subjects. Followed by the DNA extraction from the peripheral blood, genotype determination was done by PCR-restriction fragment length polymorphism method. The logistic regression analysis was used to estimate the association between the polymorphism and male infertility.
A significant difference was observed in the genotype distributions between the cases and controls. The results showed that the individuals with TC and CC genotype had an increased risk of male infertility. In addition, there was a significant association between C allele and male infertility.
HSPA1L rs2227956 polymorphism is associated with the idiopathic male infertility risk

Carpal tunnel syndrome is the most common focal neuropathy that results from pressure on a nerve. The goal of this study was to assess carpal tunnel syndrome and its associated factors such as occupation, sex, and accompanying complications in a teaching general hospital. This cross-sectional study investigated 362 patients with the diagnosis of carpal tunnel syndrome admitted in the orthopedic ward of Imam Khomeini Hospital affiliated to Tehran University of Medical Sciences in Tehran, Iran during 2000-2010. The difference in the mean age of men and women was statistically significant (P<0.0001). The percentage of men with the disease was significantly different from that of the women. The prevalence of idiopathic carpal tunnel syndrome was significantly different (P<0.0001) in comparison with carpal tunnel syndrome due to its leading causes. The most common occupation in women was first housekeeping and then hairdressing while in men it was being a worker. Diabetes Mellitus and hypothyroidisms as the leading causes of the syndrome were highly correlated with the disease (r=08, P<0.001). According to the findings, most cases of the syndrome were idiopathic. Identifying the leading causes of the disease is important because their diagnosis probably prevents unnecessary surgery. By identifying such causes and/or correction of activity styles incidence of carpal tunnel syndrome and unnecessary surgical procedures would be prevented. Evaluation of patients for underlying causes can be useful, especially in severe forms of the disease to realistically assess the need for surgical treatment.

Background and Clomiphene is the most common drug for the male idiopathic infertility treatment with different results and no valuable factor ha been suggested for prediction of treatment. Therefore the present study was designed to investigate the relationship between early morning total Serum Testosterone Level (STL) before treatment and post-clomiphene changes in the spermogram. Methods and Materials: This clinical trial study was conducted on 172 idiopathic infertile men from 2001 to 2006 in Mashad Iran. Demographic and spermogram data were recorded via questionnaires and patients were divided into 6 groups by their pre-treatment STL. Spermogram parameter changes before and after clomiphene therapy were analysed with SPSS software using t-test ANOVA and Fisher’s test. Mean age of patients was 31 years; and mean Serum Testosterone Level was 361.3ng/dl. After prescribing clomiphene recovery was observed in the spermogram of in 125 patients (72.7%) with Total Serum Testosterone Level of 200-500ng/dl (P£0.031). Early morning Serum Testosterone Level can be used as a criterion for predicting the efficacy of clomiphene in male idiopathic infertility.