جستجوی مقالات مرتبط با کلیدواژه « Menopause » در نشریات گروه « پزشکی »

Some menopausal symptoms can negatively affect people's daily activities. The work ability index (WAI) investigates employees at risk of work-related disabilities. The current study, conducted at Gonabad University of Medical Sciences, evaluated the association between the severity of symptoms during the menopausal transition and the work ability index.

In this descriptive study, 170 female subjects in the age range of menopause transition (42 to 54 years) were selected from the list of female employees at Gonabad University of Medical Sciences, using the simple random sampling method. Data were collected using a socio-demographic characteristics form, the work ability questionnaire, and the severity of menopause symptoms questionnaire. Finally, the data were analyzed in SPSS software (version 22). ANOVA and Pearson correlation coefficient were applied for data analysis.

The mean±SD of the WAI score was 38.88±6.55. The mean ± SD of intensity of physical, mental, and urogenital menopausal symptoms were 7.44±2.96, 6.46±2.67, and 5.32±2.30, respectively. The Pearson correlation coefficient between menopausal symptom severity and work ability was significantly negative (p<0.001, r=-0.418).

The reduced work ability of female employees may cause increased absenteeism, additional costs for the employer, reduced employee productivity, and increased production costs, especially in the industry and service sectors.

 Menopause is a delicate phase in the life cycle of women; therefore, it is crucial to develop a national policy that takes a personalized approach to treating menopause-related symptoms. Such a Program would aid in ensuring elderly women's quality of life and healthy life expectancy, while easing the social and financial burden of the symptoms. This study is done to study the prevalence of menopausal symptoms and perceptions of postmenopausal women. The objective of the study was to elaborate the prevalence of menopausal symptoms, menopause related quality of life and treatment seeking behavior of postmenopausal women.

 A descriptive cross-sectional study was done among 211 postmenopausal women attending Obstetrics and Gynecology OPD at Sree Balaji Medical College and Hospital. Questions were asked using a semi-structured, pretested questionnaire and menopause rating scale. The results were then analyzed.

 The median age of menopause in this study was 45 (44-46) years. 81% of the population had one or more symptoms. Almost 48% of women sought treatment for their symptoms.

The Majority of women did not seek advice for their symptoms due to a lack of knowledge. Improvement in awareness is a must to improve the quality of life in postmenopausal women.

With the growing elderly population, addressing the personal and social aspects of menopausal women is vital. Paying attention to their quality of life and solving their physical, mental and social problems can be effective in improving the health of the family and ultimately the society. This study aimed to determine the relationship between social support and quality of life in postmenopausal women.

The present study was a cross-sectional study that was conducted on 158 women. Sampling was stratified with proportional allocation method between February 2019 and August 2019 in Mahshahr health centers. The data collection tools were the demographic profile questionnaire, the Menopause Quality of Life (MENQOL) and the Phillips Social Support Questionnaire. The data were analyzed using SPSS statistical software (version 24). Pearson's, ANOVA, linear regression tests were used to analyse data.

 The average score of social support and quality of life was 84.13±10.99 (range 34-112) and 58.30±30.69 (range 110-49), respectively. There was a significant correlation between the quality of life and social support (P=0.0001). In terms of quality of life dimensions, a significant relationship was observed between social support with psychosocial (P=0.001) and physical dimension (P=0.003).

According to the significant relationship between social support and quality of life, it seems that providing social support by the family and surrounding people can be effective in improving the quality of life of postmenopausal women.

The hormonal changes associated with puberty, menstruation, pregnancy, and menopause exert varying effects on the saliva and oral health of women. The aim of this study was to investigate the effect of pregnancy and menopause on saliva (pH and flow rate) and oral health utilizing saliva sampling and oral examination.

This case-control study was performed on 120 women in three groups of pregnant women, menopause and control group (each group = 40). Subjects were evaluated for any oral lesions and were examined for DMFT, gingival index (GI) and community periodontal index (CPI), and their salivary flow rate and pH were measured. Data analysis was performed using descriptive statistics, Analysis of Covarience, partial Spearman’s correlation coefficient, adjusted logistic re-gression.

According to the ANCOVA, there was a significant difference among groups based on the pH and salivary flow rate. The highest and lowest pH has been observed in menopausal (6.80±0.42) and pregnant (6.02±0.5) group, respectively. The mean salivary flow rate was highest in the pregnant group (2.91±0.92) and lowest in the menopausal group (2.12±0.85). There was no significant difference among the groups in terms of DMFT, CPI and GI after adjusting the effect of age as covariate. There was a significant difference between the three groups in terms of xerostomia and hali-tosis (p <0.05).

Both pregnancy and menopause lead to alterations in oral health. In this investigation, the metrics of pH, xerostomia, and halitosis exhibited higher values in the menopausal group compared to the pregnant group.

Invasive angiomyxoma as a mesenchymal tumor with a high recurrence rate has been reported mainly in reproductive age according to its association with the estrogenic level of plasma. Above that, it seems there is a need for further treatment despite complete resection of the tumor, to eliminate the hormonal state. In the present study, we sought to introduce a rare case of invasive angiomyxoma in a post-menopausal but high-risk woman, discuss the relativity of risk factors in all hormonal-dependent gynecological malignancy, and intend to seek help from colleagues' opinions and experiences about treatment. It is clearly of great importance to emphasize the role of individualized medicine in such a rare case, in conclusion, there is not any debate on the role of surgical resection but the necessity of changing in lifestyle or adjuvant systemic or local therapy, and the needed duration is doubtful.

Hepatokines play an important role in the regulation of lipid and glucose metabolism, and hepatokines dysregulation can be associated with different pathological conditions such as obesity and type 2 diabetes. The present study conducted aimed to examined the effect of 12-week circuit resistance training with different intensities on the level of the insulin resistance related hepatokines, FGF-21, angiopoietin-like proteins 3 (ANGPTL3) and ANGPTL4 in obese postmenopausal women.

Forty-four postmenopausal women with average age of 56.07 ± 3.18 years participated in the present study, which randomly divided into four groups (11 subjects in each group) including control groups, low (LT), moderate (MT) and severe (HT) intensity circuit resistance training groups. The training program conducted for 12 weeks and three sessions per week. Blood samples collected before and after training interventions and the levels of desired variables were measured by ELISA method. The findings were analyzed with Graphpad Prism software and significance considered at the level of P < 0.05.

A significant decrease of FGF-21 levels was observed in the HT compared to control group (P = 0.015), but there were no significant changes in FGF-21 levels in the other groups (P < 0.05). ANGPTL3 levels decreased in LT, MT and HT groups compared to the control group (P < 0.001). In addition, decrease in the levels of ANGPTL3 in the HT group was significant compared to the LT (P < 0.001) and MT (P = 0.002) groups. The reduction of ANGPTL4 levels was significant in the three trained groups compared to the control group (P < 0.001), and also in the HT compared to the LT group (P = 0.025).

High intensity circuit resistance training compared to its low and moderate intensities can have a greater role in modulating insulin resistance by further reducing the levels of insulin resistance related hepatokines.

Vulvovaginal atrophy (VVA) is a common condition and a silent epidemic affectingmany postmenopausal women who suffer from it in silence. This study aimed to evaluate the effect ofCitrus aurantium vaginal cream on vaginal atrophy in postmenopausal women. This single-group pretest-posttest quasi-experimental study was conducted on 30postmenopausal women who were referred to the Gynecology Clinic of Imam Khomeini Hospital in thecity of Noor, Iran, from June to November 2020. Citrus aurantium vaginal cream was administered towomen diagnosed with vaginal atrophy (based on subjective symptoms of atrophy, descriptive evaluationof the vagina, vaginal pH measurement, and degree of vaginal maturation determined by vaginal smear)every night in the first two weeks and every other night for the second two weeks. Data were collectedusing the scale of subjective symptoms of vaginal atrophy; descriptive evaluation checklist of vaginalmucosa; laboratory results registration form (vaginal maturation index, vaginal maturation value, andvaginal pH) before the intervention and two and four weeks after the intervention. Data were analyzedusing SPSS software (version 24) through the analysis of variance with repeated measurements, andLSD post-hoc test. A P value less than 0.05 (P<0.05) was considered statistically significant. Citrus aurantium vaginal cream improved subjective symptoms of vaginal atrophy (P<0.001),reduced the score of descriptive evaluation of vaginal mucosa (P<0.001), decreased vaginal pH(P<0.001), and increased vaginal maturity (P<0.001). The results showed that citrus aurantium vaginal cream could improve the symptoms ofvaginal atrophy without causing serious complications. However, further studies with a control groupare suggested to confirm the findings of this study.Trial Registration Number: IRCT20200215046494N1

In middle-aged women, the postmenopausal period is associated with increased oxidative, inflammatory, and psychological stress. We intend to investigate the effect of home-based aerobic exercise (HAE) on serum levels of 8-hydroxy-2’-deoxyguanosine (8-C) and the expression of telomerase reverse transcriptase (TERT) in leukocytes of postmenopausal women.

A total of 20 sedentary postmenopausal women who had at least 12 months passed since their last menstruation participated in the study voluntarily. Their Mean±SD age, height, weight, and body mass index (BMI) were respectively 52.4±3.8 years, 161.4±3.7 cm, 74.4±6.8 kg, and 28.6±3.4 kg/m2. They were randomly divided into two groups: Home-based aerobic exercise (HAE, n=10) and inactive control (CON, n=10). HAE group undertook 4 weeks of home-based aerobic exercise (4 d/wk, intensity: 70%-80% maximal heart rate) with online supervision. Participants’ weight and fasting blood samples (12-h fasting state) were measured and taken before and 48 hours after the intervention. TERT expression in blood leukocytes and serum levels of 8-OHDG were assessed by real-time PCR and ELISA methods, respectively. The collected data were analyzed using mixed (2×2) repeated measure ANOVA and independent samples t-test in SPSS software. A significance level of P<0.05 was considered for all tests.

The findings showed that 4 weeks of HAE increased TERT expression significantly compared to the CON (ES=0.40, P<0.05). Although 8-OHDG serum level in the HAE group increased following training compared to pre-training (P<0.05), no significant difference was observed between the CON and HAE groups (P>0.05). Also, the interaction effect on 8-OHDG was not significant (ES=0.11, P>0.05). In addition, after 4 weeks of HAE, body weight and BMI significantly decreased in the training group compared to the control (P<0.05).

According to these findings, HEA effectively reduces telomere erosion and improves weight control in postmenopausal women.

Satisfactory knowledge about menopause is important for women to overcome related challenges. Women with greater knowledge about menopause are more likely to effectively manage its symptoms and navigate this life stage more successfully. This study aimed to determine the level of knowledge of Kurdish women about menopause, as well as to find its association with menopausal status and sociodemographic and obstetrical characteristics.

This cross-sectional study was conducted on perimenopausal (161) and menopausal women (751) who were recruited through non-probability convenient sampling in Kurdistan Region, Iraq, from April to June 2022. For the purpose of the study, a questionnaire was developed that included questions on demographic characteristics, obstetric and menstrual history, and knowledge about menopause. The data were analyzed by frequency, percentage, and chi-square test using SPSS version 25. Ordered logistic regression analysis was performed to determine the effect of demographic and obstetrical factors on some dependent’s variables of knowledge.

The mean age of menopausal and perimenopausal women was 54.81 ± 5.590 and 46.99±5.688 years, respectively. The participants had more knowledge about the concept and less about the health risks of menopause. On average, menopausal women were more knowledgeable about the definition of menopause compared with perimenopausal women; the difference was highly significant. Overall, the knowledge score indicated that 44% had fair knowledge, 37.6% had poor knowledge, and 18.4% had good knowledge about menopause.

Although many women view menopause as a positive life event, it is important to provide them with adequate education, so they can better understand the natural process of menopause to lead a healthy life.

Menopause is a condition for metabolic disorders. This study aimed to evaluate the effect of Nigella sativa (NS), curcumin nanomicelle (CN), lipid profile, glycemic status and 17-β estradiol (ES) levels in postmenopausal women.

Triple-blind randomized clinical trial was conducted on 120 postmenopausal women. Participants were randomly assigned to four groups: 1) NS capsule 1000 mg and CN placebo, 2) 80 mg CN capsule and NS placebo, 3) both NS and CN capsules and 4) NS and CN placebo. Participants received a single dose daily for 6 months. The serum lipid profile, glycemic control biomarkers, and ES were measured pre-and post-intervention using biochemical methods.

Total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, fasting blood sugar (FBS), fasting insulin (FI), insulin resistance (IR), and ES showed significant improvement in NS group. CN significantly reduced TC, FI, and IR, and significantly increased ES. The combination of NS-CN significantly decreased TC, LDL, FI, and IR, and increased HDL and ES. The comparison of the studied with the placebo groups showed that these changes were significant in glycemic indices and NS significantly increased estrogen.

NS, CN and NS-CN improved lipid profiles, blood sugar, and hormone levels. However, this improvement was significant in glycemic indices and estrogen levels compared to the placebo group. No superiority of combined NS-CN over NS or CN was found in this trial.

Adopting health-promoting behaviors (HPBs) is the main way to achieve a healthy lifestyle. Unhealthy lifestyle choices during postmenopausal period can lead to serious complications. Therefore, the aim of this study was to assess the status of HPBs and their individual-social factors in postmenopausal women living in Neyshabur City, Iran.

Using stratified random sampling, this cross-sectional study was performed on 300 postmenopausal women referred to Neyshabur health centers in 2022. Data was collected using demographic characteristics and HPBs questionnaires. Descriptive statistics (mean and standard deviation) and analytical statistics (T-test, one-way analysis of variance, multivariate regression test) were employed, data analysis was performed by SPSS software version 22, and the significance level was considered 0.05.  

The mean (standard deviation) of the whole score of HPBs and its dimensions including interpersonal relationships, nutrition, spiritual growth, health responsibility, stress management, and physical activity were 151.5(18.6), 31.9(4.4), 28.3 (3.9), 25.6 (3.9), 25.01(5.01), 23.9(3.7), and 16.8 (4.9), respectively. The highest and the lowest mean scores of HPBs dimensions were related to interpersonal relationships and physical activity, respectively. There were significant differences in the whole score of HPBs by level of education (P= 0.002), economic status (P < .001), and spouse's education level (P= 0.002).  

According to the results of this study, postmenopausal women’s HPBs status was moderate, Thus, certain policies should be designed and conducted to promote behaviors in postmenopausal women. Also, more attention should be paid to their physical activity.