جستجوی مقالات مرتبط با کلیدواژه « Vitamin C » در نشریات گروه « پزشکی »

There is disagreement about the correlation between serum 25-OH vitamin D (25OH-D) concentrations and ovarian reserve. The aim of this study was to evaluate the correlation between serum levels of 25OH-D and ovarian reserve parameters, including Anti-mullerian hormone (AMH), Follicle stimulating hormone (FSH), and Antral follicular count (AFC) in the tropical zone.

In this cross-sectional study, 148 infertile women were enrolled. On the third day of their cycles, vitamin D3, FSH, and AMH were measured. An ultrasound scan was done for the measurement of the ovaries AFC. Participants were divided into women with normal ovarian reserve (NOR) and women with diminished ovarian reserve (DOR). Then two groups were compared based on the levels of vitamin D.

Our findings showed that there were significant differences in vitamin D levels between the DOR and NOR groups (11.52±12.24 and 22.74±12.7, respectively), (P value <0.001). The partial Spearman correlation test depicted an inverse relationship between vitamin D and FSH (rho =-0.21, P =0.009). Also, there was a positive relationship between vitamin D and AMH and AFC, (rho=0.27, P=0.001) and (rho=0.39, P< 0.001) respectively.

This study demonstrated that there was an inverse relationship between levels of vitamin D and FSH and a positive relationship with AMH and AFC. It appears that the level of vitamin D is important in DOR.

This study aimed to assess Serum Vitamin D level and female teenage caries experience.

This study evaluated 330 healthy female Iranian students between 13 to 19 years residing in Rey city. A questionnaire collected their demographic information. They underwent clinical dental examination to determine the number of decayed (D), missing (M) and filled (F) teeth (DMFT index). The nutritional status was evaluated using the food frequency questionnaire (FFQ) by assessing the consumption of cariostatic, cariogenic, remineralizing, sticky foods and carbohydrates. The serum samples were collected to measure the serum vitamin D level using high-performance liquid chromatography (HPLC). Data were analyzed by multiple logistic regression and independent samples t-test.

The mean DMFT was 5.34±3.94. of all, 69.3% had severe vitamin D deficiency, 20.3% had moderate vitamin D deficiency and 10.4% had normal level of vitamin D. Cariostatic agents consumption had a significant inverse correlation with DMFT (P=0.006). An increase in serum level of vitamin D by more than 10.27ng/mL was associated with a reduction in prevalence of dental caries by 22%. Increased consumption of cariostatic agents by more than 89.30g/day decreased the prevalence of dental caries by 32%. No significant association was noted between the prevalence of dental caries and level of parent’s education, consanguinity of parents, level of income, place of residence, frequency of tooth brushing, dental flossing, and dental visits (P>0.05).

While the serum vitamin D level had no significant effect on DMFT, the nutritional regimen seemed to play a more important role in caries control.

The endometriosis treatment was critical due to complications associated with current drug delivery system. The present study was conducted with aim to compare the curative effect of Vitamin D3 (VTD3) and Omega–3 (OG3) with Diphereline during the treatment of endometriosis.

In this study, endometriosis was induced in different groups containing 60 adult female rats. The rat model was categorized into 6 groups untreated and treated (Olive Oil (solvent), VTD3 (42 mcg/kg/day), OG3 (450 mg/kg/day), VTD3+OG3, Diphereline (3 mg/kg/day)). The suspension containing combination of Diphereline and supplements was injected and treated for 4 weeks to analyze the effect of supplements. The interleukin -6 (IL-6) and Tumor necrosis factor – alpha (TNFα) inflammatory responses were measured from the serum samples while endometrial implants was dissected and histopathological investigation was done.

At the end of four weeks, pathologic score decreased significantly with simultaneous measurement of inflammation score of endometriotic lesion, size of implant area, IL-6, TNFα response and compared with untreated female rat. No significant different was observed in groups undergoing treatment of VTD3, OG3 and Diphereline. The combined effect of VTD3+OG3 has similar responses with Diphereline treated endometrial implants.

treatment of VTD3 deficiency and making a change in dietary habits of high-risk population for endometriosis from adolescence may also play a preventative role in adulthood.

The focus of this review study was to examine and analyze the impact of vitamins and minerals on dental implants.

In order to obtain information on the effects of vitamins and minerals on dental implants, a group of existing articles was thoroughly examined for their findings. This examination process involved the selection of specific articles that met the necessary criteria to be included in the analysis, which were then subjected to an extensive review process. The duration of this review process was over a time span of 11 years, starting from the year 2011 and concluding in the year 2022.

A total of 23 articles were included in the study, consisting of 9 clinical studies, 6 animal studies, 1 laboratory study, and 7 reviews. Clinical studies were limited due to uncertain results regarding the impact of vitamins and minerals on DIT, with most focusing on vitamin D levels rather than other nutrients.

It has been concluded that vitamins and minerals play an important role in forming bone tissue. The lack of these essential elements may result in several diseases, such as diabetes mellitus and osteoporosis. It is therefore recommended to increase the levels of vitamins and minerals in patients before undergoing dental implant treatment (DIT), even though the quality of the patient’s bone can also impact the success of the implant. Consequently, the patient’s diet should be modified, and essential supplements and vitamins should be administered to ensure optimal implant success.

Studies on the relationship between vitamin B12 and gestational diabetes mellitus (GDM) have shown different results. Given the lack of research in this area in Iran and the inconsistent findings of studies carried out in other nations, this study was conducted in light of the significance of the problem, particularly with regard to the health of expectant mothers.

This case-control study was performed on 120 pregnant women referred to Ayatollah Rouhani hospital in Babol, private offices, and health centers to evaluate the vitamin B12 level in women with and without GDM. GDM was defined as 1) after oral ingestion of 75g glucose, fasting plasma glucose level (PGL) >92 mg/dL, 1-hour PGL >180mg/dL, or 2-hour PGL >153mg/ dL during 24-28 weeks of gestational age, or 2) in the 100-g oral glucose tolerance test (OGTT), PGL >195 mg/dL, one-hour PGL >180 mg/dL, 2-hour PGL >155, and 3-hour PGL >140, and GDM was diagnosed if there were at least 2 out of 4 mentioned cases. According to the above definition, pregnant women with GDM were placed in the case group, while those without GDM were placed in the control group. After 8 hours of fasting, intravenous blood samples were taken and sent to the laboratory for measurement, and vitamin B12 deficiency was considered <99 pg/dL after 28 gestational weeks.

Vitamin B12 deficiency was prevalent in 14.2% of 120 pregnant women studied. Vitamin B12 deficiency was more common in GDM women than in non-GDM women (58.8%-41.2%). A normal level of vitamin B12 could act as a protective factor against GDM. The vitamin B12 levels increased in the 30- to 40-year-old women with GDM. In other age groups, vitamin B12 levels were higher in non-GDM women than in GDM women. Among 17 women with vitamin B12 deficiency, 52.9% had a fasting PGL >92.

The results of the present study suggest that measuring vitamin B12 levels may aid in the early diagnosis of GDM and prevent maternal and fetal complications.

Many single nucleotide polymorphisms affect the incidence of Alzheimer’s disease (AD). This investigation aimed to consider the frequency of the C677T single nucleotide polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene in Alzheimer’s patients.

This study was conducted in two groups of control (n = 80) and patient (n = 80) with a ratio of 1: 1 male to female. Amplification-refractory mutation system-Polymerase Chain Reaction (ARMS-PCR) method was used to study mutations and ELISA was used to measure homocysteine and the chemiluminescence method was used to measure cholesterol, vitamin B12 and folate.

Based on the results of the PCR test of the MTHFR gene, the incidence rate of mutation in the healthy allele was 44.6% and in the mutant allele was 27.9% of the total study population.

In this study, it was discovered that an increase in cholesterol levels is related with an increased risk of developing the disease, but more studies are needed to confirm this. It should also be noted that this increase is not related to the MTHFR gene polymorphism at the C677T position.

Today, the COVID19 pandemic is one of the most important health system challenges in the world, which doesn’t have specific treatment yet. It includes a wide range of respiratory and non-respiratory signs and symptoms, that lead to hospitalization and intensive care units.

In this study, 78 patients in two groups of 39 patients were included. The case group included 39 COVID19 patients who had specified sign in CT scans and factors of viral infection, high serum ferritin, increased inflammatory factor in the blood. There were two intervention groups (receiving deferoxamine and vitamin C) and the control group (receiving only official protocol drugs of the country). All patients were admitted to the ICU of Shohada-e-Tajrish Hospital and underwent complete cardiorespiratory monitoring. All changes in Spo2, hemodynamics, serum ferritin and CRP were recorded before the study.

This study presented that improved patient had lower ferritin levels than those who were still ill. In addition, prescribing deferoxamine as an adjunct to vitamin C can prevent cytokine storms that was effective for improving the patients with COVID19.

In conclusion. According to the role of deferoxamine and vitamin C in significantly reducing inflammatory factors of ferritin and CRP, they can be used as an adjunctive therapy in patients with COVID19.

Purpose of Review: 

Tendinopathy, also called tendinitis, is a common issue in musculoskeletal consultations. Tendon healing is inferior to normal due to low metabolic rate and poor vascularity. R. damascena has anti-inflammatory, antioxidant, and healing effects. This study aims to investigate R. damascene's effects on Achilles tendon injury using histopathology and biomechanical evaluations.

Wistar rats were divided into seven groups, including a control group and three groups with tendinitis, that were given different doses of Hydroalcoholic Extract of R. damascene (HERD) (250, 500, 1000 mg/kg) intraperitoneally. Dexamethasone and Vitamin E were used in the reference groups. The Achilles tendon was injured, and the extract was administered for 20 days. Histopathological assessment and antioxidant activity were determined by serum malondialdehyde levels and ferric-reducing antioxidant power assays on days 10 and 20.

Different dosages of HERD, particularly 1000 mg, improved inflammatory intensity, angiogenesis, fibroplasia, and complete tendon regeneration on the 10th and 20th days after the injury, while also reducing unsaturated fatty acid peroxidation and increasing the whole serum's antioxidant capacity on the 20th day.

After a thorough review, it can be concluded that HERD is an effective anti-inflammatory agent and analgesic for preventing and treating tendinitis. Furthermore, it has been deemed safe and well-tolerated, making it a promising option for those seeking relief from the symptoms of tendinitis.

Current data indicate that serum vitamin D and susceptible C-reactive protein (hs-CRP) levels, both indicative of the inflammatory state, have the potential to predict the onset and severity of chronic pain. Therefore, the objective was to assess the intensity of pain experienced after breast cancer treatment and its relationship with these two parameters.
In this cross-sectional study between 2019 and 2021, 201 patients were enrolled. The McGill Pain Questionnaire was employed to evaluate localized pain intensity at the site six months after the conclusion of cancer treatments. Patients were stratified based on the type of breast surgery, with or without a tissue expander, axillary region surgery, chemotherapy treatment, radiotherapy treatment, serum vitamin D levels, serum hs-CRP levels, and pain intensity. Data analysis was performed using SPSS 21 software with a significance level set at 0.05.
Among the patients, 67.6% (136 individuals) reported mild pain, 31.3% (63 individuals) reported moderate pain, and 1% (2 individuals) reported severe pain. The results of this study demonstrated a positive correlation between high serum hs-CRP levels and increased pain intensity, with serum marker levels being higher in patients experiencing more severe pain compared with those with milder pain. However, no statistically significant association was observed between various serum concentrations of vitamin D and pain intensity (P = 0.12).
Elevated levels of inflammatory factors, such as hs-CRP, are linked to a higher likelihood of developing chronic post-surgical pain.

The combination of TNF-α inhibitors and vitamin D in colitis remains to be elucidated. In the present study, we revealed the benefit of infliximab (IFX) and vitamin D in a mouse model of Ulcerative colitis (UC). 

A dextran sulfate sodium-induced colitis model was used. The therapeutic effect of the combination was evaluated by symptom and histopathology analysis. The synergistic mechanism was explored by detecting the regulatory effect of the combined therapy on Regulatory T cell (Treg) differentiation.

IFX and 1,25-dihydroxyvitamin D3 (VitD3) synergistically prevented the development of colitis by improving clinical signs, pathological and hematological manifestation, and inhibiting intestinal inflammation (decreasing TNF-α, IL-1β, and IL-6). Coadministration of IFX (2.5 mg/kg) with VitD3 or IFX (5.0 mg/kg) with VitD3 was more effective than administration of IFX (2.5 mg/kg, 5.0 mg/kg). There was no difference in therapeutic effect between IFX (5.0 mg/kg) and VitD3+ IFX (2.5 mg/kg) groups or between the VitD3+IFX (5.0 mg/kg) and VitD3+ Azathioprine (AZA) groups. VitD3 or combination therapy showed more powerful regulation of splenetic Treg differentiation and IL-10 production than IFX alone. Moreover, VitD3 alone or in combination induced higher levels of Foxp3 and IL-10 than IFX in colon tissue. In ulcerative colitis patients, serum VitD3 levels positively correlated with Treg levels.

VitD3 and IFX synergistically inhibit colitis based on their powerful regulation of Treg differentiation. VitD3 combined with IFX is an alternative therapy for patients who are intolerant to standard   doses of IFX or combination of IFX and AZA.

An ongoing debate has been raised on whether is better to use total or free calcidiol as a screening test in the population.

In winter and summer, free calcidiol, total calcitriol, and vitamin D binding protein (DBP) concentrations were determined by immunoenzymatic assays in 326 adults (161 males, 165 females). These included 99 osteoporotic patients, 53 type 1 and 51 type 2 diabetics, and 123 athletic healthy persons, all from northern Greece.

In the whole sample, free calcidiol mean concentrations differed significantly (p < 0.001) between males (5.53 pg/ml) and females (4.68 pg/ml). Free calcidiol was significantly greater in the athletic healthy group (6.02 pg/ml) than in the three patient groups, and lowest in the osteoporosis group (3.69 pg/ml). Total calcitriol mean concentration did not differ significantly between genders in the whole sample (p = 0.896) or in the study groups, except for type 2 diabetics (males 38.33 pg/ml, females 54.52 pg/ml, p = 0.001). It was significantly less in the osteoporotics (34.61 pg/ml) than in the athletic healthy group (41.65 pg/ml, p = 0.037) and type 1 diabetics (43.73 pg/ml, p = 0.030), whereas it did not differ significantly between the other study groups. The DBP mean concentrations were not significantly different between genders in the whole sample and the study groups nor among the study groups (p = 0.467).

Comparisons with our previously reported results of total calcidiol suggest the measurement of free calcidiol offers nothing more than that, and total calcitriol is not a sensitive measure for assessing vitamin D status.

Coagulopathy as a reversible dose-dependent side effect of rifampin is rarely observed in patient on rifampin in associate to inducing vitamin K deficiency. We reported a middle-aged man on a brucellosis three-drug regimen (including rifampin) who was admitted to the hospital due to a rheumatoid arthritis flare-up with increased partial thrombin time and international normalized ratio. Abnormal coagulation tests were discovered as an unintentional finding in the absence of clinical signs of bleeding. However, the coagulation tests returned to normal in 48 hours by withdrawing rifampin and administering 2.5 mg of oral vitamin K. The patient was discharged with a new brucellosis regimen including doxycycline and trimethoprim/sulfamethoxazole.

We aimed to determine the level of serum vitamin D and serum ferritin in four groups’ children and adolescents.

This descriptive/analytical study was conducted in 2019 on children and adolescents with thalasse-mia aged 7-18 years in Ahvaz, Iran. Overall, 160 patients with the target inclusion and exclusion criteria were assigned into four groups (n=40) of people withthalassemia minor, thalassemia major, iron deficiency anemia and healthy individuals. The level of ferritin and vitamin D was assessed. Mann-Whitney test, Wilcoxon test and Spearman's correlation test were used as well as SPSS Statistics V21.

Themean age of the participants was 13.07 ± 3.82 yr and 100 people (62.5%) were male. In terms of vitamin D deficiency, 16 people (40%) had severe deficiency in iron deficiency group. The highest level of ferri-tin was found in thalassemia major group and thelowest in iron deficiency group. Regarding the level of vita-min D and ferritin in the healthy group, there was a statistically significant difference between mean vitamin D and serum ferritin levels (P=0.027). In iron deficiency group, this level of ferritin was observed with mild defi-ciency (P=0.017). In thalassemia major group, the increase in ferritin was associated with severe vitamin D de-ficiency (P=0.05.

Severe vitamin D is seen in thalassemia major due to the increase in ferritin, but moderate defi-ciency of this vitamin in healthy people and mild deficiency in iron deficiency anemia group was observed con-sidering the normal levels of ferritin.

Methotrexate (MTX) is a drug with anti-inflammatory and immunosuppressive effects and is also a folic acid antagonist. Our aim in this study is to determine the molecular mechanisms of cardiotoxicity caused by MTX, a chemotherapeutic drug, and to evaluate the protective effects of vitamin B12 on this toxicity. 

A total of 32 rats were used in our study and 4 groups were formed. Control group, Vit B12 group (3 μg/kg B12 for 15 days, IP), MTX group (20 mg/kg MTX single dose on day 8 of the experiment, IP), MTX +Vit B12 group (3 μg/kg, IP ), Vit B12 throughout the 15 days, and a single dose of 20 mg/kg MTX (IP) on day 8 of the experiment. Immunohistochemically, expressions of hypoxia-inducible factor 1α (HIF1-α), vascular endothelial growth factor receptor-2 (VEGFR-2), erythropoietin (EPO), and interleukin-6 (IL-6) were evaluated in the heart tissue. Total catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) levels were measured in the heart tissue. At the same time, ANP and NT-proBNP levels were measured in the blood serum.

In the study, the expression of HIF1-α and VEGFR-2 increased significantly in the MTX group, while IL-6 and EPO significantly decreased. At the same time, CAT and SOD levels were significantly decreased and MDA levels increased significantly in the MTX group. While vitamin B12 significantly corrected all these values, it also greatly reduced the increases in ANP and NT-proBNP levels caused by MTX.

It is important to use Vit B12 before and after MTX administration to replace the folate that MTX has reduced.

Chronic gastrointestinal inflammation, known as inflammatory bowel disease (IBD), is associated with severe morbidity and mortality. According to recent research, microbiota composition, vitamin D level, and the immune system are the three most important elements that should have been taken into account in determining susceptibility to IBD disease. There is broad agreement that alterations in the composition and metabolism of the gut microbiota are related to IBD susceptibility (dysbiosis). In IBD disease, the composition of the gastrointestinal microbiome is changed and the beneficial ones are replaced by the pathogenic microbiome. Furthermore, a drop in serum vitamin D levels is noted in IBD patients. Vitamin D prevents the onset of IBD by reducing inflammatory cytokines and cells as well as limiting the expansion of pathogenic microbiota by inducing the release of antimicrobial peptides (AMPs). However, more research is needed to completely comprehend the intricate relationships between the microbiota and vitamin D, it is suggested that modifying these factors could be an alternative treatment for IBD disorders. To restore dysbiosis, using FMT, probiotics, and vitamin D supplementation have been proposed as alternative treatments. The purpose of this article is to review the involvement of these key parameters and their interactions in the susceptibility and pathogenesis of IBD.

In Indonesia, Acute respiratory infection (ARI) and diarrhea-related morbidity and mortality in children less than five years old still remain a significant public health concern. In this relation, energy, protein, zinc, and vitamins C, B, D, E, and A are essential nutrients to mitigate morbidity and mortality. Vitamin A was shown to play a crucial role in human development, growth, and immune function that can protect infants against infectious diseases such as  ARI and diarrhea. So this study aimed to compare the effect of beefliver and vitamin A supplementation for breastfeeding mothers on the incidence of ARI and diarrhea in infants. In a randomized control trial design, 40 participants aged 20-35 years were allocated into two groups of beef liver and vitamin A supplementations. The beef liver supplementation group received eight servings during two months postpartum, or no later than the 7th day after giving birth; while the vitamin A supplementation group received two vitamin A capsules no later than the 7th day postpartum. The incidence of ARI significantly differed, while there was no significant difference in incidence of infant diarrhea between the two groups. In breastfeeding mothers, administering beef liver (75 grams/ day equivalent to 402,000 IU) could reduce the frequency of ARI and infant diarrhea more effectively than supplementation with two vitamin A capsules (equivalent to 400,000 IU). There was no difference in morbidity of infant diarrhea for mothers who received two vitamin A capsules.

The prevalence of inflammatory bowel diseases (IBDs) has increased in recent decades. The incidence of osteoporosis in the population with IBD is higher than in the normal population. Therefore, it seems necessary to carefully examine the risk factors associated with decreased bone mineral density (BMD) among these patients.

Methods and Materials: 

Patients with IBD completed a questionnaire including demographic data, drug history, underlying disease (past medical history), and family history, then their bone density was measured with a DEXA device. Also, laboratory samples were prepared. Densitometry results were placed in three groups: normal, osteoporotic, and osteopenia. All of the data was analyzed by SPSS version 23 software.

This study was conducted on 63 patients (58 patients with ulcerative colitis (UC) and 5 patients with Crohn's disease (CD)). The bone density was normal in 40 patients, 16 had osteopenia and 7 had osteoporosis. There was a significant relationship between bone density and age (P < 0.001), smoking (P=0.049), past medical history (P< 0.001), extraintestinal involvement (P=0.008), duration (P=0.023) and menopause (P=0.002). Also, the amount of use of corticosteroid drugs (P=0.014), the level of calcium (P=0.017), and vitamin D (P< 0.001) in the blood had a significant relationship with bone density.

In our study, we showed that age, smoking status, underlying conditions, extraintestinal involvement, corticosteroid use, levels of vitamin D and calcium, and menopause are risk factors for an increased risk for decreased BMD in IBD patients.