Effect of Cisplatin Encapsulated in Nanoarchaeosome on Growth and Extension of Breast Cancer Cells in MCF-7 Cell Line
Author(s):
Abstract:
Aim and
Background
The purpose of this research is to have increased level of stability and fatality rate of cisplatin by application of encapsulation process in nanoarchaeosome. Success of this research is proved by examining the results obtained from MTT tests on Breast cancer cells in MCF-7 cell line. Materials And Methods
After cultivation of MCF-7 cell line in culture room، fatality rate of encapsulated cisplatin was compared with normal cisplatin by performing the related MTT tests. Output numbers from Elisa Reader explained the death rate of cancer cells. Results
During the MTT tests performed on MCF-7 cell line، effect rate of encapsulated cisplatin was compared with normal cisplatin. Examining the figures resulted from Elisa Reader output numbers، shows that stability and fatality rate of encapsulated drug is extremely higher than normal drug. Conclusion
Nanoarchaeosome is used for encapsulating of cisplatin. This process causes increasing the stability of drug in addition to the rise of fatality rate. This was clearly shown by examining the Breast cancer cells in MCF-7 cell line.Keywords:
Cisplatin , Nanoarchaeosome , Loading , MTT Test , MCF , 7 Cell Line
Language:
Persian
Published:
New Cellular & Molecular Biotechnology Journal, Volume:2 Issue: 8, 2012
Pages:
67 to 71
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