Effect of Angelica archangelica root hydro-alcoholic extract on the blood cells of small laboratory mice

Angelica archangelica is one of the medicinal herbs in traditional medicine which is effective in hematopoiesis. In the present study، the effect of interperitoneal injection of Angelica archangelica root’s hydroalcoholic extract in different doses on the count of red and white blood cells، change in hemoglobin and hematocrit، mean globular volume، the average size of hemoglobin and the hemoglobin average weight ratio in the Balb/c mouse، were studied. In this experimental study، 40 mature Balb/c male mice were divided into control، placebo (with saline injection) and 3 treatment groups (injected with 50، 100 and 200mg/kg doses of Angelica archangelica root’s hydroalcoholic extract every other day for 20 days). Indices of red and white blood cells’ count، hematocrit and hemoglobin mean، mean corpuscular volume، hemoglobin average volume and hemoglobin average weight ratio were measured for each group separately. The results obtained were evaluated using SPSS 11. 5 software and Duncan''s one-way ANOVA test. The average number of white blood cells in the first، second and third treatment groups was significantly higher than control group (p<0. 05). The average number of white blood cells in the third group (200 mg/kg) was significantly higher than the other groups (p<0. 05). There was no significant difference between the mean of hematocrit، hemoglobin، MCV، MCH and MCHC of the groups (p>0. 05). The extract of Angelica archangelica is effective in hematopoiesis process with the increase in the number of red blood cells and also with the increase in the number of white blood cells in the immune system support.