Effect of Cydonia oblonga seed's extract and silver nanoparticles on wound healing in mice infected with Staphylococcus aureus

Staphylococcus aureus is one of the most important causes of skin infections. The resistance of this bacterium to antibiotics is increasing every day. Studies have shown that the ethanolic and acetonic extracts of Quince seeds and silver nanoparticles can prevent the growth of S. aureus. In this study, the effect of ethanolic and aceonic extract of Quince seed's and silver nanoparticles investigated against skin burns infection due S. aureus in animal model. First, the ethanolic and acetonic extract of Quince seeds and silver nanoparticle were prepared. Then, on the shoulders of 36 male mice burn wound was created. Wheal was infected with S. aureus. The mice were divided into 6 groups of 6. And each group were treated with its special ointment (ointment of silver nanoparticles, ethanol yield acetonic extract of Quince, mupirocin, vaselin, and no treatment group, respectively). Every day until eleven day the condition of wound healing rate was measured and compared. The results showed that the group treated with ethanolic and acetonic extracts of Quince seed's had the greatest impact on wound healing. And its effects better than mupirocin and silver nanoparticles reported. The results showed that the Quince seeds extracts can be used in healing skin infections caused by S. aureus.