Acute and delayed response of aerobic training on omentin plasma levels in diabetic rats

Diabetes is a metabolic disorder that is caused by a decline in insulin secretion or insulin resistance. Omentin -1 is a recently discovered protein that is expressed in visceral adipose tissue and secreted and increases insulin sensitivity. The aim of present study was to investigate the effect of an aerobic exercise session on plasma omentin -1. In this study, diabetes was induced by streptozotocin (50 mg/kg) injection in a single dose in mice. 40 male Wistar rats with average weight of 165 ±5 g were randomly divided into a control group and three exercise groups. The training group ran a session with a speed of 20 meters per minute for 50 minutes on the treadmill. Mice were anesthetized inseparated groups, immediately, 4 hr after exercise and 24 hr after exercise and sampling was done. Finally, plasma levels of omentin were determined by ELISA. The results indicate that plasma levels of omentin-1 did not have any significant changes in all training groups compared with the control group.Discussion and It is likely that omentin-1 plasma levels increase after an exercise session in diabetic rats may have an anti-inflammatory effect.