Evaluation incidence of Helicobacter pylori infection in gastric adenocarsinoma

Gastric adenocarcinoma is one of the most common cancers worldwide. Most epidemiological studies have indicated the role of H. pylori infection on increased risk of gastric adenocarcinoma. The aim of the present study was to investigate the presence of this microorganism in gastric cancer in different regions of the stomach and to compare it with non malignant lesions. Samples were obtained from 50 confirmed cases of gastric adenocarcinoma who underwent gastrectomy during the years of 2007- 2008 at Ghaem and Omid hospitals of Mashhad. Gastric tissue of 50 patients who underwent endoscopy without gastric cancer was obtained as control samples. All patients were matched with regard to age and sex. The urease test and histology were used for the diagnosis of H. pylori infection. The prevalence of H. pylori was compared between the two groups. The data analysis was performed using SPSS version 16. through t student، Chi-square test، and Fisher exact tests. The prevalence of H. pylori infection in gastric adenocarcinoma group was 92% and in the control group was 60%. The prevalence of H. pylori infection in gastric adenocarcinoma patients was 100% in the antropyloric region and 95% in the body of the stomach. There is a significant correlation between Helicobacter pylori infection and risk of gastric adenocarcinoma.