Cytotoxic Effects of Myrtus communis Extract on Hela and MCF7 Cancer Cells

This study aimed to investigate the effects of Myrtus communis extract in 10, 7.5, 5, 2.5, 1.25, 0.625, 0.312, 0.156 mg/ml concentration on Hela and MCF7 cell lines after 72 h using the MTT assay. Hela and MCF7 cells were cultured in RPMI1640 medium containing fetal bovine serum, penicillin and streptomycin and incubated at 37 ° C atmosphere containing 5% CO2 and 95% humidity in sterile flasks. Results show that ethanolic extract of M. communis in 1.25 mg/ml (p ≤ 0.05), and 0.312, 0.156 (p ≤ 0.02) concentration, was significantly reduced Hela cell growth compared to control, after 72 h. The highest percentage of growth inhibition at 0.625 mg/ml concentration was % 82.33. For MCF7 cells, ethanolic extract of M. communis in 2.5, 1.25, 0/312 mg/ml (p≤ 0/02) and 0.625 (p≤ 0/001) concentration was significantly reduced MCF7 cell growth compared to control, after 72 h. The highest percentage of growth inhibition at 1.25 mg/ml concentration was 70.64 %. The results suggest that ethanolic extract of M. communis has inhibitory effects on cell growth both on Hela and MCF7 cell line.