Effect of Short Term Creatine Monohydrate Supplementation on Homocysteine Levels in Active Male after Exhaustive exercise

The purpose of this study was to investigate the effect of short-term Creatine monohydrate supplementation on homocysteine concentrations in young active male after exhaustive exercise. Twelve soccer players (age 22.11±2.02 years, vo2max 56.51±2.31, homocysteine concentrations 13.45±0.59 μmol/l) assigned to Creatine monohydrate (n=6) and placebo (n=6) groups randomly. Experimental group received 0.3g per kg of body weight daily Creatine monohydrate for five days. Blood sampling was taken in 12h fasting in both pre and post test. Nutritional status and physical activity levels were similar for all subjects one week before and during the study. There was no significant difference in initial levels of plasma homocysteine, 12 and plasma creatinine (P≤0.5). Homocysteine levels of Creatine -folate, B monohydrate group decreased significantly in base (P=0.017) and immediately after exercise (P=0.013). No significant difference was observed between groups in post test (P=0.542). The difference between the two groups in the changes in homocysteine levels after supplementation and exhaustive exercise was statistically significant (p=0.002). Short-term Creatine monohydrate supplementation and acute exercise may decrease homocysteine levels in young active male.