Effect of Lotus Corniculatus L. Extracts on Wound Healing In Male Diabetic Rats Induced With Streptozocin

Diabetic wound is a common complication of diabetes. The aim of this study was to evaluate the effects of topical application of Lotus corniculatus hydroalcoholic extract on cutaneous wound healing in diabetic rats induced by streptozocin (STZ) in comparison with Phenytoin ointment in rat.Methods and Materials: In this interventional experimental study, male Wistar rats (250±20 g) were divided randomly to normal and diabetic groups. Diabetes was induced by intraperitoneal injection of STZ (60 mg/kg). After anesthesia, full thickness skin of upper dorsal part of rats removed in 2cm2 area. 24 hours after operation, wound in each animal treated once daily with L. corniculatus hydroalcoholic extract (40%) or phenytoin ointment (1%) in normal and diabetic group. Control group received no treatment. Wound surface area measured until 24th postoperative days. The time required for complete healing was also recorded. The progress of wound healing in diabetic animals was slower than in normal animals, and also healing effect of L. corniculatus extract compared with controls and normal Phenytoin and diabetic test groups was significant (p<0.001). Topical application of L. corniculatus might be accelerate the wound healing after seven day and it was comparable to phenytoin cream in diabetes-related complications.