The Effect of Two Modes of Treadmill Training on the Adaptation of Inflammatory Biomarkers in Menopausal Obese Rats

Inflammation has been proposed as one of the most important risk factors for cardiovascular diseases. Many researchers have reported a positive relationship between inflammation and blood lipids. This study was designed to investigate the effect of different modes (continuous and intermittent) of training on systemic inflammation and blood lipids. 56 menopausal obese wistar14848 rats (weight 325±4.93 g, age 21 months, at least three months after their menopause) were randomly divided into the control, continuous or intermittent training groups. The training program was carried out five days a week for 6 and/or 12 weeks. Blood samples were gathered in three phases of baseline, after 6 weeks and after 12 weeks. Results showed that C-reactive protein (CRP) insignificantly reduced in both training groups after 6 weeks, but its reduction was significant after 12 weeks in both groups. Although a significant decrease was detected in training groups after 6 and 12 weeks, there was no significant difference between continuous and intermittent traininggroups after 6 and 12 weeks compared with the control group. Decrease in low density lipoprotein and increase in high density lipoprotein following continuous and intermittent training represents an important intervention in CRP reduction, and therefore, it can be concluded that both types of training lower inflammation and have anti-inflammatory and cardio-protective effects on the heart.