The Effect of Creatine Monohydrate Supplementation on Oxidative Response Induced by One Bout of Downhill Running in Male Mountaineers

Due to the limited research on the effects of creatine monohydrate on exerciseinduced oxidative responses, the present study was conducted to identify the effect of creatine monohydrate supplementation on the response of some indexes of oxidative stress following one bout of downhill running in male mountaineers. 20 male elite mountaineers (age 24.5±1.8 years) received 300 mg/kg/day creatine monohydrate (n=10) or dextrose (n=10) for five consecutive days. Then, all subjects participated in the running protocol with 65% reserve heart rate and -15% incline for 30 minutes. Changes in serum total antioxidant capacity (TAC) and Malondialdehyde (MDA) were analyzed by ANOVA with repeated measures in four phases at α≤0.05. The results showed that the basal serum TAC significantly (P=0.004) increased following creatine supplementation (19.29%). The 24-hour increased response of serum MDA in creatine group (22.13%) was significantly (P<0.001) less than the placebo group (45.75%). The short-term creatine monohydrate supplementation may reduce the increased response of serum MDA in male mountaineers after downhill running through increasing basal serum TAC.