Effect of 8 week resistance training on plasma levels of omentin-1 in male rats with insulin resistance

Omentin-1 is an adipokine that is highly secreted in visceral adipose tissue compared to subcutaneous adipose tissue and increases insulin sensitivity. The aim of the present study was to investigate the effect of 8-week resistance training on omentin-1 plasma levels in insulin resistant male rats. Twenty-four Wistar male rats with average weight 161±23 gr were randomly divided into three groups: health control، insulin resistance control، insulin resistance training. After fructose-inducing insulin resistance to the two groups of insulin resistance control and insulin resistance training bleeding in all subjects was done then training group was exercised for 8 weeks (3d/wk). In the training protocol، a ladder was used on which rats carriedpen loads suspended from their tails. After the training session omentin-1، insulin، glucose، lipids profile plasma concentration and (HOMA-IR) index were measured. The results of this study indicate that 8 weeks of resistance training can cause significant increase of omentin-1 and HDL-C plasma concentration in insulin resistance training group (P≤0. 05) and insulin، glucose، cholesterol، LDL-C، TG plasma concentration and (HOMA-IR) index were decreased. This study indicates that resistance training increases omentin-1 plasma concentration in insulin resistance rats and improves lipids and metabolic profile.