POLYAMINES IMPROVE ANTI-BLOOD LACTATE ACCUMULATION IN AN ACIDOSIS RAT MODEL

Lactic acidosis (lactate accumulation and pH downfall) occurs in a number of clinical conditions and has deleterious effects on the patient’s survival. Sodium bicarbonate and tromethamine are administrated in these conditions. However, these compounds only adjust the blood pH and do not affect the lactate level. In this study, administration of polyamines was hypothesized as a novel approach for treatment of lactate accumulation. For this purpose, the impact of different polyamines on an experimental model of acidosis was evaluated.
In this study, rats were divided into different groups and type B lactic acidosis was induced in the groups. Blood lactate was measured before and after acidosis in the rats along with polyamines administration.
The obtained results indicated that polyamines of putrescine, cadaverine and spermidine had significant effects to decrease the lactate level, while, sodium bicarbonate and tromethamine did not affect its level.
The findings supported the advantageous effects of polyamines in treatment of lactate accumulation and can have implications for treatment of acidosis in human. Therefore, administration of polyamines is proposed as an effective treatment for lactic acidosis.