The Preotective effects of Okra Powder (Abelmoschus esculentus) on Histological and Histochemical Changes of Pancreatic Beta Cells and Liver Tissue of Diabetic Rat
Author(s):
Abstract:
Background And Objective
Since Abelmoschus esculentus plant has many medical benefits, the present study aimed to investigate the therapeutic effects of Okra Powder (Abelmoschus esculentus) against high-fat diet fed-streptozotocin (HFD/STZ)-induced diabetic rats.Methods
In this experimental study, 25 Wistar Albino female rats were randomly divided into 5 groups: I: control group; II: healthy rats receiving A. esculentus (200 mg/kg); III (HFD/STZ group): Rats fed with high-fat diet (HFD) (60% fat) for 4 weeks and then injected low-dose STZ (35 mg/kg); IV: diabetic rats receiving A. esculentus (200mg/kg) and V: diabetic rats receiving metformin (200 mg/kg). At the end of experiment, biochemical parameters, including Fasting Blood Glucose (FBG), insulin levels, Homa-IR index, ALT, AST and lipid profile were measured. Pancreas and Liver samples were removed, and 5-6 µ sections were prepared and stained by H&E and aldehyde fuchsin staining.Results
All the biochemical parameters, except HDL-C and insulin, were increased in diabetic rats, while these parameters were decreased in Okra supplementation group compared to diabetic rats (pConclusion
Okra powder improved biochemical parameters, liver structure and restoration of beta cells of pancreas in diabetic rats. Thus, it can be considered a complementary therapy to improve diabetic patients.Keywords:
Diabetes , Histomorphometry , Liver , Beta cells , Okra
Language:
Persian
Published:
Journal of Ardabil University of Medical Sciences, Volume:17 Issue: 63, 2017
Pages:
32 to 45
https://magiran.com/p1691533
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