Electrochemical Oxidation of Masalazine Drug at Poly(glutamic acid) Modified Glassy Carbon Electrode

A sensitive and quick responsive analytical method was developed for the electrochemical oxidation of masalazine (MSZ) using poly (glutamic acid) modified glassy carbon electrode (MGCE). The modified electrode shows electrocatalytic activity towards the oxidation of MSZ drug in 0.2 M phosphate buffer solution (PBS) of pH 7.4 by cyclic voltammetric (CV) technique. The limit of detection was calculated to be 23.94 nM at modified electrode. The effect of scan rate study reveals an adsorption controlled electrode phenomenon. The modified electrode can be used as an analytical tool for the determination MSZ in pharmaceutical formulations.