pattan siddappa ganesh

Poly (alanine) modified carbon paste electrode (CPE) was fabricated for the determination of 5-amino salicylic acid (5-ASA) by cyclic voltammetric technique. The poly (alanine) modified CPE exhibited a high sensitivity towards the oxidation of 5-ASA. The effect of scan rate was found to be surface-controlled diffusion process and the concentration study was conducted between the range of 20-180 µM. The limit of detection (3 S/M) and limit of quantification (10 S/M) were calculated and found to be 0.23 µM and 0.76 µM respectively. Because of high sensitivity in the electro-oxidation, the fabricated poly (alanine) modified CPE can be used as a promising electrochemical sensor for the determination of 5-ASA in both commercial as well as in pharmaceutical samples.

Niacinamide was electropolymerised on the surface of carbon paste electrode by cyclic voltammetric technique. The modified electrode showed an excellent electrocatalytic activity towards the oxidation of norepinephrine (NE) and ascorbic acid (AA). The response of the sensor was evaluated towards the different NE concentration in the range 40.98 to 244.3 µM, the oxidation peak current was linearly increased with varying NE concentration and the detection limit was calculated to be 0.21 µM. The modified electrode showed excellent selectivity in the determination of NE in presence of large excess of AA and UA. The voltammetric responses were stable and resistant to fouling. The proposed electrode can be used for the real sample analysis in medical, pharmaceutical and biotechnological sectors.

The poly (toluidine blue) modified carbon paste electrode (MCPE) was fabricated for the determination of catechol (CC) and hydroquinone (HQ) by cyclic voltammetric and differential pulse voltammetric techniques. The poly (toluidine blue) MCPE exhibited high sensitivity and selectivity towards the determination of CC and HQ in a binary mixture. The effect of scan rate reveals an adsorption controlled phenomenon at the modified electrode surface. In order to show the selectivity of the electrode, an interference study was performed by varying the concentration of one analyte while keeping other analyte constant which in turn gives a satisfactory result. Overall, a simple experimental procedure for fabricating the poly (toluidine blue) MCPE was reported with the merits of sensitivity, selectivity, reproducibility and anti-fouling property towards the determination of electroactive species.

The poly (congo red) film was developed on the surface of carbon paste electrode by electrochemical method. The fabricated poly (congo red) modified carbon paste electrode exhibited excellent electrocatalytic activity towards the oxidation of catechol (CC) and hydroquinone (HQ) in a binary mixture by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. The scan rate effect was found to be adsorption controlled electrode process. The interference study was done by varying the concentration of one species while other kept constant. Overall a sensitive and selective method was developed for the electroanalysis of CC and HQ.

A sensitive and quick responsive analytical method was developed for the electrochemical oxidation of masalazine (MSZ) using poly (glutamic acid) modified glassy carbon electrode (MGCE). The modified electrode shows electrocatalytic activity towards the oxidation of MSZ drug in 0.2 M phosphate buffer solution (PBS) of pH 7.4 by cyclic voltammetric (CV) technique. The limit of detection was calculated to be 23.94 nM at modified electrode. The effect of scan rate study reveals an adsorption controlled electrode phenomenon. The modified electrode can be used as an analytical tool for the determination MSZ in pharmaceutical formulations.

The poly(methionine) modified carbon paste electrode (MCPE) was fabricated for the electroanalysis of catechol (CC) and hydroquinone (HQ) in phosphate buffer solution (PBS) of pH 7.4 by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. The modified electrode shows selective and sensitive response for the simultaneous determination of CC and HQ in a binary mixture. The peak to peak separation of CC and HQ was 0.115 V and 0.112 V by CV and DPV techniques respectively. The effect of concentration and scan rate reveals the electrode process was controlled by the adsorption of the analytes. This study provides a new method for the modification of working electrode for the voltammetric determination of the CC and HQ.

A non-ionic surfactant triton X-100 (TX-100) modified carbon paste electrode (TX-100/CPE) was fabricated for the electrocatalytic oxidation of catechol (CC) and hydroquinone (HQ) by cyclic voltammetric (CV) technique. The study of concentration variation for both CC and HQ was conducted; the lower limit of detection was calculated to be 0.59 µM and 0.56 µM for CC and HQ by CV technique. The fabricated TX-100/CPE was achieved the voltammetric separation of CC and HQ in a mixture by CV and differential pulse voltammetric (DPV) techniques. The effect of scan rate on the binary mixture of CC and HQ was examined; results suggest the electrode process was controlled by the adsorption phenomenon. The elimination of the fouling effect by the oxidised product was achieved by the TX-100/CPE.

The carbon paste electrode (CPE) was modified by electropolymerisation of amoxicillin in 0.2 M acetate buffer solution (ABS) of pH 5.0 by using cyclic voltammetric (CV) technique. The modified electrode was used for the electrochemical determination of dopamine (DA). The poly(amoxicillin) modified CPE showed excellent electrocatalytic activity towards the oxidation of DA. The study of variation in concentration and scan rate shows that the electrode process was diffusion-controlled. Further the modified electrode was used for the simultaneous determination of DA and ascorbic acid (AA) by CV technique.

The multi-walled carbon nanotube modified carbon paste electrode (MWCNTMCPE) was used for the voltammetric investigation of folic acid (FA) and uric acid (UA) in physiological pH of 7.4. The scan rate and concentration study reveals that the electrode process was controlled by diffusion of the analytes. The sensitive separation for the binary mixture of FA and UA was observed by cyclic voltammetric and differential pulse voltammetric techniques. A simple modification procedure was reported for the determination of FA and UA.