Comparison between oxidative stress (8-OhdG, MDA) and atherogenic risk (AIP) factors in type 2 diabetics and healthy people: a case-control study

Oxidative stress and atherogenic dyslipidemia are the main complications in type 2 diabetics. The present study aimed at comparing between serum 8-hydroxydeoxyguanosine (8-OHdG) and atherogenic index plasma (ARP) levels in type 2 diabetics and normal people.
In this study the relevant data of 50 type 2 diabetics ,who had referred to Emam Reza educational hospital and serum samples of random 50 healthy subjects, aged 27-70 yrs, was collected. The levels of 8-OHdG, AIP, and MDA in type II diabetics were measured by means of ELISA and TBARS, respectively. Their lipid profiles and plasma autherogenic indices were assessed through an autoanalyser.
The case and control groups were homogenized regarding some demographic components such as age and gender .It was found that serum levels of 8OHdG,MDA, and AIP were significantly higher in the patients compared to the healthy controls ,aged 27-70 yrs (P The lipid peroxidation and DNA oxidation in diabetic patients were indicated high oxidative stress in these patients, which can cause post complications such as cardiovascular disease.