Comparison of Amnion Membrane with Bio-Gide in Conjunction with Bio-Oss in Treatment of Intrabony Periodontal Defects

Guided Tissue Regeneration (GTR) is one of the effective and predictable surgical procedures for treatment of periodontal intrabony defects. The present study aimed to clinically evaluate and compare the efficacy of Amnion Membrane (AM) Bio-Oss and Bio-Gide Bio-Oss in GTR treatment of intrabony periodontal defects.
In this study, chronic periodontitis patients who need periodontal regenerative surgery received phase I of periodontal treatment. After 1 month follow up, 10 patients with bilateral intrabony defects and radiographic evidence of intrabony component of ≥ 4 mm and probing depth ≥ 6 mm were randomly assigned into two experimental and control groups. The experimental group was treated by placement of AM Bio-Oss, while the control group was managed by placement of Bio-Gide Bio-Oss. Clinical parameters, including Periodontal Pocket Depth (PPD), Probing Bone (PB) level, Clinical Attachment Level (CAL), and gingival recession (REC), were recorded at baseline and 6 months after the surgery. Then, the data were analyzed using T-test.
A significant difference was observed regarding CAL, PB, and PPD after 6 months compared to before the surgery. In addition, significant changes were observed regarding CAL, PB, PPD, and REC in the control group. However, the mean changes in CAL, PB, and PPD before and after the surgery was not significant between the two groups. Yet, a significant increase was found in REC in the control group compared to the experimental group (P=0.009).
Both AM and Bio-Gide in conjunction with Bio-Oss resulted in improvement of the clinical periodontal parameters. According to the results, AM did not induce any significant gingival recession. Thus, AM is recommended as a new barrier membrane in GTR treatment.