Comparison of the Effect of Different Volumes of Intravenous Crystalloid Infusion on Postoperative Nausea and Vomiting in Laparoscopic Cholecystectomy under General Anesthesia
Postoperative nausea and vomiting (PONV) is the most common and unpleasant postoperative complication. It seems that fluid-therapy during the surgery is effective on the onset of this complication. The aim of this study was to compare the effect of 30 and 10 ml/kg crystalloid infusion on PONV after laparoscopic cholecystectomy under general anesthesia.
In this study, 146 patients who were randomly divided into two equal groups were evaluated. One group received 30 ml/kg and the other 10 ml/kg Ringer solution as a preoperative intravenous bolus. The incidence and intensity of PONV, and the need for a rescue antiemetic were recorded by anesthesiologist in recovery, and 6, 12, and 24 hours after surgery.
The incidence of PONV was not significantly difference between the two groups. The intensity of vomiting in group 30 ml/kg was significantly lower 12 hours after surgery (P < 0.01). The antiemetic drugs were used significantly less in group 30 ml/kg than other group.
Preoperative intravenous administration of 30 ml/kg crystalloid compared with crystalloid 10 ml/kg in patients undergoing laparoscopic cholecystectomy did not reduce the incidence of nausea and vomiting, but reduced the intensity of vomiting 12 hours after surgery, and antiemetic use 24 hours after surgery.
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