Effect of Silymarin on Blood Glucose and Hnf4a Gene Expression in Streptozotocin-Induced Diabetic Male Wistar Rats

Diabetes mitigates beta cells and impairs their function. Silymarin improves this disorder and decreases and also significantly increases the expression of insulin. The purpose of this study was to evaluate the effect of Silymarin on blood glucose and expression Hnf4a gene is in streptozotocin-diabetic male rats.

  In this research, 42 male rats were randomly selected and divided into 7 groups of heparin, diabetic rats with diabetes mellitus and streptozotocin, and their fasting blood glucose was measured. Then, doses of 50, 100, and 150 were given to the Marinchr('39')s slider recipients.The rats were then anesthetized with medication. A portion of the pancreatic tissue was isolated and used to evaluate the expression of Hnf4a gene using Real Time RT PCR.

 Investigating the expression of Hnf4a expression at 150 mg/kg doses in rats receiving silymarin showed that in this dose significant reduction of Hnf4a gene was introduced as an effective dose (P-value <0.05). In the future, silymarin can be considered as a Herbal medicine used to treat diabetes.

 By studying the results of this study, it can be said that the silymarin plant has anti-inflammatory effects and can be effective in reducing diabetes mellitus.