Effect of Metformin on the Menstrual Regulation in Polycystic Ovarian Syndrome

One of the causes of AUB in women is Polycystic Ovarian Syndrome (PCOS). This study was undertaken to evaluate the effectivenes of metformin therapy for the treatment of menstrual disturbances in PCOS. This clinical trail study was carried out on 120 women with PCOS in Bahman clinic in 1380-1381. The patients received metformin 1500 mg daily for 6 months and their menstrual pattern was assessed monthly. 16 out of 120 women (13.3%) had regular menses after 2 months and 80 women (66.7%) had regular menstration after 6 months. Age of women did not effect the treatment, but BMI was effective, whereas the mean of BMI in treated patients were more. The side effects of metformin were nausea (16.7%), Anorexia (16.7%) and diarrhea (13.3%) We conclude that menstural disturbances in women with PCOS were improved by administration of metformin.