Role of rs10840293 and rs17087335 in Patients with Coronary Artery Disease in an Iranian Population

Previous genome-wide association studies (GWASs) have shown an increased CAD risk associated with single nucleotide polymorphisms (SNPs) in SWAP70 (rs10840293) and Rest- NOA1 (rs17087335). This study aimed to investigate the relationship between rs10840293 and rs17087335 polymorphism with coronary artery disease in the Iranian population.

This study was a case-control study with the case-base sampling method for the control group. Genomic DNA was extracted from the peripheral blood collected from 150 patients with CAD and 150 healthy controls. Polymorphisms were genotyped by Taq-Man technology. SPSS software was used for statistical analysis.

The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (P>0.05). Allelic frequencies and genotype distributions of rs10840293 and rs17087335 did not show statistical significance between patients with POAG and control subjects (P<0.05).

To the best of our knowledge, this is the first report concerning the association between SWAP70 and RestNOA1 gene polymorphisms and CAD in an Iranian population. Our data suggest that rs1533428 and rs12994401 are unlikely major risk factors for CAD in an Iranian population.