The effect of ten weeks of aerobic training with sesamin supplementation on non-enzymatic antioxidant

Intense physical activity releases oxygen free radicals and causes oxidative damage in biological macromolecules. One of the ways to counter the adverse effects of oxidative stress from exercise is to use oral antioxidant supplements. The purpose of this study was to investigate the effect of 10- weeks’ aerobic training with sesamin supplementation on non-enzymatic stress oxidative markers in male athletes.

40 male athletes with at least 4 years of continuous exercise experience participated voluntarily in this quasi-experimental study. Subjects were randomly divided into four groups: placebo (n=10), exercise (n=10), exercise + supplement (n=10) and supplement (n=10). The intervention was for ten weeks included an aerobic exercise (four days per week / 35-30 minutes) and supplementation of sesamine (3 tablets 17 mg per week). Blood samples were taken at six stages including pre-test (baseline immediately after and 24 hours after a heavy training session) and post-test (after ten weeks of aerobic training and 24 hours after an intensive training session). Data were analyzed by repeated measure ANOVA at the significant level p <0.05.

After 10 weeks of aerobic training and supplementation of sesamine, plasma levels of TAC and uric acid significantly increased  (P = 0.001) and bilirubin (P = 0.007) and total plasma protein (P = 0.001) were decreased significantly.

It seems that supplementation of sesamine with aerobic activity with proper volume to improve non-enzymatic antioxidant status of athletes may be useful And strengthen their antioxidant system.