Cholecystectomy:Long term effect on serum lipid profile and VitaminD

The association between cholecystectomyand abnormal lipids and later increase in the risk of diseases related to dyslipidemia showed controversial results. Thisstudy aims to evaluate theassociation of lipid profile and VitaminD level before and after cholecystectomy.

Ninety-eightpatients with symptomatic gallstones were studied prospectively. Plasma concentration of cholesterol, triglycerides, LDL, HDL and vitamin D was analyzed preoperatively and postoperatively after six months of cholecystectomy. None of the patients received any lipid-lowering drug or dietary restriction.

Sixty-seven (68.4%) female and 31 (31.6%) male patients were studied for six months. There was a significant increase in total serum cholesterol besides a significant decrease in vitamin D and HDL serum level after six months. Also, there was a non-significant increase in the serum level of LDL and triglyceride. In stone based sub analysis the same results achieved.

There was a significant decrease in plasma concentration of vitamin D and HDL and the significantincrease in cholesterol , triglyceride,andLDL in cholecystectomy patients postoperatively. These changes in plasma lipids and VitaminD are likely to have a significant effect on the development of differentdisease related to dyslipidemia such as coronaryartery disease and low bone density after cholecystectomy in the long term.