Effect of 12 weeks elastic band resistance training on mir-34a expression and cardiovascular risk factors in obese elderly women.

Obesity is a global epidemic and a risk factor for many diseases. miRNAs are increasing as pathological molecular determinants of pathologic processes. The aim of this study was to investigate the effect of 12 weeks elastic band resistance training on mir-34a expression and cardiovascular risk factors in obese elderly women.

In this single blind randomized clinical trial (RCT), 49 elderly women with obesity (based on the results of the DEXA test, age 64.13 ± 3.68, fat percentage 45.4 ± 6.56, BMI 33. 1 ± 3.71) were divided into two groups: control (n=22) and training (n = 27). The training group performed elastic band resistance training for 12 weeks and three sessions at week for all major muscle groups. 48 hours before and after 12 weeks of intervention, blood sampling was performed.

The results of the intergroup comparisons indicated a significant decrease in mir-34a expression and LDL levels and a significant increase in HDL in the training group compared to the control group (P = 0.05, P = 0.03, P = 0.03, respectively), whereas There was no significant difference in body weight, body mass index, fat percentage, total cholesterol and CRP.

It seems that 12 weeks elastic band resistance training have been able to modulate and reduce the serum concentration of mir-34a in obese elderly women, which was associated with a decrease in LDL levels and increase levels of HDL(p≤0.05), although body mass index, fat percentage, total cholesterol and CRP Significant changes were not observed, which may be due to the type and intensity of the exercises, which requires further investigation in this field.