Effect of cream containing green tea extract and pedophylline solution on the process of reducing genital wart lesions

Genital wart is a common sexually transmitted infection which impairs the patient's quality of life. One of the plants which is mentioned in traditional medicine for the treatment of genital warts is green tea extract. Considering the need for new and improved treatments for external anogenital warts, as well as the emphasis on the use of home and herbal medicines and its prevalence in families and its use by the patient and saving the health costs due to the lack of need to refer to physician, this study was performed with aim to compare the effect of green tea extract cream with pedophylline solution on the reduction of genital wart lesions.

This clinical trial study was performed in 2018-2019 on 76 women with genital warts. The subjects were randomly divided into the intervention and control groups. In the intervention group, green tea extract cream was used 3 times a day and in the control group, pedophiline solution was used once a week. The patients in both groups referred every two weeks until 12 weeks or complete recovery of lesions and the number of dimensions and percentage of reduction of lesions were recorded in the lesion assessment form. The validity and reliability of the tool were confirmed by the views of the experts and Cronbach's alpha coefficient r=89%. Data were analyzed by SPSS software (version 22). P

The number and dimensions of lesions were significant between the two groups of green tea extract and pedophylline in weeks 4, 6 and 8 after the intervention compared with before the intervention (p <0.001) and showed better results in the pedophylline group. But, according to the results of Mann-Whitney test, no statistically significant difference was found between the two groups in the number and size of lesions during the 10 weeks after treatment (p <0.001). The number and dimensions of lesions were significant between the two groups during 10 weeks of intervention compared to before the intervention (p <0.001).

The rate of healing of lesions after the end of treatment in the green tea group was the same as pedophylline, so considering the success of the results of the present study, it is recommended to use this product as a suitable alternative to pedophylline in the treatment of genital warts