Pathogenesis of COVID-19; Acute Auto-inflammatory Disease (Endotheliopathica & Leukocytoclastica COVIDicus)
Moslem Bahadori , Shahriar Dabiri* , Abdolreza Javadi , Simin Shamsi Meymandi , Sajjadeh Movahedinia , Manzumeh Shamsi Meymandi , Parisa Khorasani , Mehrdad Farrokhnia , Meysam Yousefi , Farhad Sarrafzadeh , Hamid Abosaidi , Saeedeh Shojaeepour , Abbas Mortazaizadeh , Mitra Rezaei , Bahram Dabiri , Nader Mohabati , Hanie Ranjbar , Sara Rashidinejad , Abdolamir Feizy
The pathogenesis of the COVID19 pandemic, that has killed one million nine hundred people and infected more the 90 million until end of 2020, has been studied by many researchers. Here, we try to explain its biological behavior based on our recent autopsy information and review of literature.
In this study, patients with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) result were considered eligible for enrollment. Histopathological examinations were done on 13 people who were hospitalized in Afzalipour hospital, Kerman, Iran. Clinical and laboratory data were reviewed. Tissue examination was done by light microscopy, immunohistochemistry and electron microscopy.
The most frequent co-morbidity in the patients was cardiovascular disease. The common initial symptoms of COVID-19 infection were dyspnea and cough. In all cases, the number of white blood cells was higher than the normal range. Common histopathological findings were variable degrees of vasculitis as degenerative to necrotic changes of endothelium and trafficking of inflammatory cells in the vessel wall with fibrinoid necrosis. Tissue damage included interstitial acute inflammatory cells reaction with degenerative to necrotic changes of the parenchymal cells. CD34 and Factor VIII immunohistochemistry staining showed endothelial cell degeneration to necrosis at the vessel wall and infiltration by inflammatory cells. Electron microscopic features confirmed the degenerative damages in the endothelial cells.
Our histopathological studies suggest that the main focus of the viral damage is the endothelial cells (endotheliopathica) in involved organs. Also, our findings suggest that degeneration of leukocytes occurs at the site of inflammation and release of cytokines (leukocytoclastica) resulting in a cytokine storm.
-
O-6-Methylguanine-DNA Methyltransferase, C-MYC, and EBER Status in Diffuse Large B-Cell Lymphoma of Central Nervous System
Alireza Sadeghipour, Hadi Mohagheghian, *, Farid Kosari, Ahmad Monabati
International Journal of Molecular and Cellular Medicine, Autumn 2024 -
Cytogenetics and Molecular Abnormalities in Pediatric Patients with Acute Myeloid Leukemia in a Referral Center in Tehran, Iran
Mahshid Heidary Sadegh, Maniya Mozafari, Mohammad Vasei, , Marzieh Hosseini, Moeinadin Safavi *
Middle East Journal of Cancer, Jan 2025