Evaluation of the effect of aloe vera gel on ovarian tissue structure in nicotine-receiving rats

Exposure to nicotine and cigarette smoke has dangerous effects on pregnant women, fetal and neonatal health, and fertility rates. Aloe vera is one of the few medicinal plants that has maintained its popularity for a long time due to its many medicinal properties. Therefore, in the present study, the protective effect of aloe vera gel on ovarian histological changes in nicotine-receiving rats was investigated. For this purpose, 32 female Wistar rats into 4 control groups (normal diet), nicotine (6 weeks nicotine at 0.2 mg / kg body weight of animals injected intra peritoneal), nicotine-aloe vera (6 weeks nicotine injection + gel) Aloe vera plant (400 mg / kg body weight of animals orally), Aloe vera group (6 weeks aloe vera gel by the above method and amount) were divided. At the end of the course, the mice were facilitated and the ovaries were transferred to a histological laboratory to prepare a tissue slide and perform hematoxylin-eosin staining. The results showed that after nicotine treatment, weight loss, ovarian weight, number of healthy and active follicles, new corpus luteum and increase in the number of atretic follicles were observed. But the use of aloe vera gel was able to improve all the microscopic complications and disorders and macroscopic changes caused by nicotine injection. Therefore, oral consumption of aloe vera gel can reduce or inhibit the harmful effects of nicotine in tobacco or drugs on the ovaries and fertility in women.