The Effect of Aerobic Training and Octopamine Supplement on Gene Expression Levels of TNF-α and NFkB in the Heart Tissue of Rats Exposed to Deep Frying Oil

Message:
Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
Background

Deep-fried oils (DFOs) used in the preparation of fast food are considered as a risk factor which can affect the immune system. On the other hand, physical activities, especially aerobic training and the use of herbal supplements, have a significant effect on reducing the effects of abusing these foods and improving the function of the immune system.

Objective

The objective of this study was to investigate the effect of aerobic training (T) and octapamine (O) supplementation on NFkB and TNF-α gene expression levels in the heart tissue of rats poisoned with DFO.

Methodology

In this experimental study, 25 male Wistar rats were purchased and assigned in 5 groups of 5 animals, including: 1) control, 2) DFO, 3) DFO+T, 4) DFO+O, and 5) DFO+T+O. During 4 weeks, rats in the groups 2 to 5 received DFO by gavage, groups 3 and 5 ran on the treadmill 5 sessions a week with moderate intensity, and groups 4 and 5 were given 81 μmol/kg octamine supplement intraperitoneally five days a week. The Kolmogorov-Smirnov test, independent samples t-test and two-way analysis of variance were used to analyze the research findings (p<0.05).

Findings

DFO had a significant effect on increasing NFkB (p=0.001) and TNFα (p=0.001) levels; training had a significant effect on the reduction of NFkB (p=0.001) and TNF-α (p=0.001); also, octapamine supplementation had a significant effect on the reduction of NFkB (p=0.001) and TNF-α (p=0.001). Interactive effects of training and octapamine consumption on NFkB (p=0.001) and TNF-α (p=0.001) levels were significant.

Conclusion

It seems that aerobic training and octapamine supplementation synergistically have anti-inflammatory effects in the heart tissue of DFOpoisoned rats.

Language:
Persian
Published:
Journal of Researches in Sport Sciences and Medical, Volume:2 Issue: 7, 2022
Pages:
12 to 18
https://magiran.com/p2484058  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 1,390,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!