The Effect of Aerobic Training and Octopamine Supplement on Gene Expression Levels of TNF-α and NFkB in the Heart Tissue of Rats Exposed to Deep Frying Oil
Deep-fried oils (DFOs) used in the preparation of fast food are considered as a risk factor which can affect the immune system. On the other hand, physical activities, especially aerobic training and the use of herbal supplements, have a significant effect on reducing the effects of abusing these foods and improving the function of the immune system.
The objective of this study was to investigate the effect of aerobic training (T) and octapamine (O) supplementation on NFkB and TNF-α gene expression levels in the heart tissue of rats poisoned with DFO.
In this experimental study, 25 male Wistar rats were purchased and assigned in 5 groups of 5 animals, including: 1) control, 2) DFO, 3) DFO+T, 4) DFO+O, and 5) DFO+T+O. During 4 weeks, rats in the groups 2 to 5 received DFO by gavage, groups 3 and 5 ran on the treadmill 5 sessions a week with moderate intensity, and groups 4 and 5 were given 81 μmol/kg octamine supplement intraperitoneally five days a week. The Kolmogorov-Smirnov test, independent samples t-test and two-way analysis of variance were used to analyze the research findings (p<0.05).
DFO had a significant effect on increasing NFkB (p=0.001) and TNFα (p=0.001) levels; training had a significant effect on the reduction of NFkB (p=0.001) and TNF-α (p=0.001); also, octapamine supplementation had a significant effect on the reduction of NFkB (p=0.001) and TNF-α (p=0.001). Interactive effects of training and octapamine consumption on NFkB (p=0.001) and TNF-α (p=0.001) levels were significant.
It seems that aerobic training and octapamine supplementation synergistically have anti-inflammatory effects in the heart tissue of DFOpoisoned rats.
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